Fail-safe TET system for implanted life support devices

用于植入生命支持设备的故障安全 TET 系统

• 批准号: 6834492
• 负责人: Robert T.V. Kung
• 金额: $ 8.16万
• 依托单位: ABIOMED, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834492
• 关键词: assistive device /technology; biomedical device power system; biomedical equipment safety; body movement; circulatory assist; quality of life; technology /technique development

DESCRIPTION (provided by applicant): Cardiac assist devices are increasingly being used for long term support. As patient survival times increase substantially, long-term management of the patients will increasingly play a role in suitability of these devices as destination therapies. Infection, primarily due to cable entry site(s), remains a primary complication for these patients. To-date, the only practical approach to completely eliminate long-term issues associated with cable entry site infections is to use a TET (Transcutaneous Energy Transfer) system. A TET system, is an electro-magnetic power transfer system, which can send substantial electrical power across a patient's intact skin, thereby eliminating cable entry site infections. The ultimate objective of the research proposed here is to develop a fail-safe TET system with substantial reduction in power transfer sensitivity to patient movement. ABIOMED has already developed a first-generation TET system currently in use in the clinical trial of the AbioCor total artificial heart. This system, although highly effective in a clinical setting, has demonstrated the need for a fail-safe operation as well as for reduced sensitivity to patient movement. Starting with the current ABIOMED TET as a base, detailed studies in phase I will develop a novel, fail-safe TET system and fully characterize its performance. The need for a trouble free, user friendly TET system is already very visible, and will become increasingly important as more patients are discharged home with destination cardiac support prostheses. For these patients a robust, lightweight, complication-free power source will play a critical role in achieving a near-normal quality of life.

描述（由申请人提供）： 心脏辅助装置越来越多地用于长期支持。 随着患者生存时间的大幅增加，患者的长期管理将在这些器械作为目标治疗的适用性方面发挥越来越大的作用。 感染，主要是由于电缆进入部位，仍然是这些患者的主要并发症。 迄今为止，完全消除与电缆进入部位感染相关的长期问题的唯一实用方法是使用泰特（经皮能量传输）系统。 泰特系统是一种电磁功率传输系统，其可以在患者的完整皮肤上发送大量的电力，从而消除电缆入口部位的感染。 本研究的最终目标是开发一种故障安全的泰特系统，该系统可大幅降低功率传输对患者运动的敏感性。 ABIOMED已经开发了第一代泰特系统，目前正在AbioCor全人工心脏的临床试验中使用。 该系统虽然在临床环境中非常有效，但已经证明需要故障安全操作以及降低对患者运动的敏感性。 以目前的ABIOMED泰特为基础，第一阶段的详细研究将开发一种新型的故障安全泰特系统，并充分表征其性能。 对无故障、用户友好的泰特系统的需求已经非常明显，并且随着更多的患者带着目的地心脏支持假体出院回家，这种需求将变得越来越重要。 对于这些患者来说，一个坚固、轻便、无并发症的电源将在实现接近正常的生活质量方面发挥关键作用。