Recoverable Homogeneous Chiral Phosphine Ligands

可回收的均质手性膦配体

• 批准号: 6785675
• 负责人: Mikhail Gololobov
• 金额: $ 10万
• 依托单位: POLIUM TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6785675
• 关键词: catalyst; chemical registry /resource; combinatorial chemistry; ligands; phosphines; protonation; solvent extraction; stereoisomer; technology /technique development

DESCRIPTION (provided by applicant): This project (Phase I and Phase II combined) is devoted to the development of a library of homogeneous catalysts, recoverable through liquid/liquid methods, used for asymmetric hydrogenation. Polium Technologies, Inc is seeking SBIR funds for this project because we see a significant demand for such products from industry, but the company cannot afford their development without external funding. The significance of this project is a direct consequence of a huge demand for new chiral technologies fueled by the $160 billion market of single-enantiomer pharmaceutical products. Technology developed in the course of this project would significantly simplify the large-scale separation and recycling of expensive chiral catalysts. This would increase cost-effectiveness of prospective chiral catalytic processes, making them attractive to manufacture a wider range of single-enantiomer compounds. In 2002, the market for such technologies was $7 billion, and it is projected to reach $15 billion by 2009. in Phase I Polium Technologies, Inc will perform a feasibility study. Specifically we will (a) prepare several homogeneous catalysts recoverable by liquid/liquid extraction, starting from several of the most frequently used chiral phosphine ligands; (b) demonstrate activity of these catalysts in model hydrogenation reactions. As of July 29, 2003, there are no publications or patents on catalytic systems for asymmetric synthesis recoverable by liquid/liquid processes or their use in catalysis.

项目描述（申请人提供）：本项目（一期和二期合并）致力于开发均相催化剂库，可通过液/液法回收，用于不对称加氢。Polium Technologies， Inc正在为该项目寻求SBIR资金，因为我们看到工业对此类产品的巨大需求，但如果没有外部资金，公司无法承担其开发费用。单对映体药物产品的1600亿美元市场推动了对新手性技术的巨大需求，这个项目的重要性直接导致了这一需求。该项目开发的技术将大大简化昂贵的手性催化剂的大规模分离和回收。这将增加未来手性催化过程的成本效益，使它们具有制造更广泛的单对映体化合物的吸引力。2002年，这类技术的市场规模为70亿美元，预计到2009年将达到150亿美元。在第一阶段，Polium技术公司将进行可行性研究。具体来说，我们将(a)从几种最常用的手性膦配体开始，制备几种通过液/液萃取可回收的均相催化剂；(b)证明这些催化剂在模型氢化反应中的活性。截至2003年7月29日，还没有关于不对称合成催化系统的出版物或专利，可以通过液/液工艺或它们在催化中的应用进行回收。