Biomimetic Synthesis of Dimeric Natural Products

二聚天然产物的仿生合成

• 批准号: DP140101429
• 负责人: Dr Andrew Lawrence
• 金额: --
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101429
• 关键词: Biomimetic; Synthesis; Dimeric; Natural; Products

The aim of this research is to use nature as a source of inspiration and direction to improve and develop synthetic organic chemistry. Through targeted total syntheses this project will investigate and learn about the highly sophisticated way nature utilises dimerizations to rapidly generate molecular complexity. This project will demonstrate the power of this biomimetic strategy by synthesising a wide variety of complex dimeric natural products including phenylethanoids, alkaloids, lignans, terpenes and coumarins. The expected outcome will be uniquely efficient synthetic strategies that significantly surpass all previous approaches and new synthetic methodology that will be of broad use in organic synthesis.

本研究的目的是利用自然作为灵感和方向的来源，以改善和发展合成有机化学。通过有针对性的全合成，该项目将调查和了解自然界利用二聚反应快速产生分子复杂性的高度复杂的方式。该项目将通过合成各种复杂的二聚天然产物，包括苯乙醇，生物碱，木脂素，萜烯和香豆素，来展示这种仿生策略的力量。预期的结果将是独特有效的合成策略，显着超过所有以前的方法和新的合成方法，将在有机合成中广泛使用。