Characterising the proteolytic network of plant cathepsin B during stress.

植物是表达具有工业生物技术应用价值的重组蛋白的有吸引力的平台。高价值蛋白在烟草叶片中的高表达水平会导致局部细胞程序性死亡，从而限制目的重组蛋白的产量。提高我们对植物中PCD调控的理解有望允许设计改进的植物品系，例如改进的烟草品系。该项目预计将确定可进行基因组编辑的新型靶基因，以使蛋白质表达宿主中的PCD失效，并提高用于生物技术过程的重组蛋白的产量。

Plants are attractive platforms to express recombinant proteins of high value for applications in industrial biotechnology. High expression level of high-value proteins in tobacco leaves can lead to local Programmed Cell Death and therefore limit the yield of the recombinant protein of interest. Improving our understanding of the regulation of PCD in plant is expected to allow the design of improved plant strain, for example an improved tobacco strain. The project is expected to identify novel target genes that could be subjected to genome editing in order to disable PCD in protein-expression hosts and increase the yield of recombinant proteins to be used in biotech processes.