Characterising the proteolytic network of plant cathepsin B during stress.

表征胁迫期间植物组织蛋白酶 B 的蛋白水解网络。

• 批准号: 2441685
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2441685
• 关键词: Characterising; proteolytic; network; plant; cathepsin

Plants are attractive platforms to express recombinant proteins of high value for applications in industrial biotechnology. High expression level of high-value proteins in tobacco leaves can lead to local Programmed Cell Death and therefore limit the yield of the recombinant protein of interest. Improving our understanding of the regulation of PCD in plant is expected to allow the design of improved plant strain, for example an improved tobacco strain. The project is expected to identify novel target genes that could be subjected to genome editing in order to disable PCD in protein-expression hosts and increase the yield of recombinant proteins to be used in biotech processes.

植物是有吸引力的表达重组蛋白的平台，在工业生物技术中具有很高的应用价值。高价值蛋白在烟草叶片中的高表达水平会导致局部细胞程序性死亡，从而限制重组蛋白的产量。提高我们对植物中PCD调控的理解有望使我们能够设计出改良的植物品系，例如改良的烟草品系。该项目预计将确定可以进行基因组编辑的新目标基因，以使蛋白质表达宿主中的PCD失效，并增加用于生物技术过程的重组蛋白质的产量。