Examining the role of extracellular myeloperoxidase in the pathogenesis, identification and treatment of high-risk unstable and ruptured atherosclerotic plaque

检查细胞外髓过氧化物酶在高危不稳定和破裂动脉粥样硬化斑块的发病机制、识别和治疗中的作用

• 批准号: nhmrc : 2002759
• 金额: $ 10.34万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/examining-role-extracellular-atherosclerotic-plaque/1780452
• 关键词: Examining; role; extracellular; myeloperoxidase; pathogenesis

Vascular inflammation has emerged as a key driver and therapeutic target for stroke and heart attack. Existing diagnostic techniques and treatments do not target inflammation so that residual inflammatory risk remains. There is a need to identify patients with active inflammation who may benefit from treatment. Myeloperoxidase is an inflammatory enzyme abundant in plaque at risk of rupture and subsequent stroke or heart attack and presents as a potential diagnostic tool and therapeutic target.

血管炎症已成为中风和心脏病发作的关键驱动因素和治疗靶点。现有的诊断技术和治疗方法不针对炎症，因此残留的炎症风险仍然存在。有必要确定可能从治疗中受益的活动性炎症患者。髓过氧化物酶是一种炎性酶，在斑块中含量丰富，有破裂和随后中风或心脏病发作的风险，是一种潜在的诊断工具和治疗靶点。