Real Time Risk of Mortality in Critically III Children

描述（由申请人提供）： 儿科重症监护病房（PICU）最重要的功能是为临床医生提供先进的计算机化监测能力，以评估患者的临床状态并跟踪他们对各种干预措施的反应。我们假设，整合和分析多个临床重要变量： a.真实的实时连续生理监测参数（即体温、心率、血压、中心静脉压、脉冲血氧饱和度和潮气末二氧化碳浓度）; B.儿童死亡率的既定指标（心率变异性的功率频谱分析）; C.结合间歇性的、基于生理的器官功能测量，已知许多测量可预测PRISM III的死亡率（动脉血气、血清器官特异性酶水平等）;以及 D.来自PRISM III的已知的死亡率人口统计学预测器将使用先进的信号处理、统计、数据融合和挖掘技术，在危重病儿童中创建即将发生的死亡率和/或不稳定性的风险的真实的连续的、综合的复合指数（REALTROMINS -死亡率和不稳定性的真实的时间风险）。随着这些目标的实现，新的、先进的重症监护技术将会出现，它将提供真实的时间 持续评估A）这些儿童的危重病水平和B）多种医疗干预措施的有效性，这将有助于危重病儿童恢复健康。

DESCRIPTION (provided by applicant): The most important function of a pediatric intensive care unit (PICU) is to provide advanced computerized monitoring capabilities to clinicians to evaluate the clinical status of patients and to track their response to a wide range of interventions. We hypothesize that integrating and analyzing multiple, clinically important variables as: a. real time continuous physiologic monitoring parameters (i.e. temperature, heart rate, blood pressure, central venous pressure, pulsed oximetry, and end tidal carbon dioxide concentrations); b. with established indices of pediatric mortality (power prectral analysis of heart rate variability); c. coupled with intermittent, physiologic based measures of organ function, many known to predict mortality from PRISM III (arterial blood gases, serum organ specific enzyme levels, etc); and d. known demographic predictors of mortality from PRISM III will create a real time, continuous, integrated, composite index of risk for impending mortality and/or instability (REALTROMINS - Real Time Risk of Mortality and INStability) in critically ill children using advanced signal processing, statistical, data fusion and mining techniques. With the accomplishment of these goals, new, advanced critical care monitoring technology will have emerged that will provide real time continuous assessment of A) the level of critical illness in these children and B) the efficacy of a multitude of medical interventions, that will help return critically ill children back to health.