Therapeutic and Diagnostic Factors as Related to Cancer
与癌症相关的治疗和诊断因素
基本信息
- 批准号:6952506
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:breast implants breast neoplasms cancer risk clinical research disease /therapy duration estrogens female fertility fertility promoting drug hormone related neoplasm /cancer hormone therapy human data human subject longitudinal human study medical records menopause neoplasm /cancer diagnosis ovary neoplasms questionnaires therapy adverse effect uterus neoplasms women's health
项目摘要
A major emphasis of this project has been to define the relationship of exogenous hormones to subsequent cancer risk. Using a similar approach as had been used to examine the effects of exogenous hormones on breast cancer risk, analyses within the context of a large screening program showed an association of menopausal hormone use with the risk of ovarian cancer. These analyses showed risk to increase with years of use of hormones, particularly when the preparation used was unopposed estrogens. Relationships with endometrial cancer are being pursued with additional follow-up data.
Also of interest is the relationship of breast implants to subsequent cancer risk. Breast cancer risk has been of concern, given that breast implants can interfere with the mammographic visualization of lesions. However, in a large retrospective study that we conducted, we found no evidence for an alteration in breast cancer risk. These patients also generally did not experience alterations in other cancer sites, although elevations were observed in the risk of lung and brain cancers, the explanation for which remains unclear. In a mortality analysis, implant patients had signficantly elevated risks of death from suicide, but other causes of death were similar to the general population. Currently underway are analyses of risk of connective tissue diseases related to breast implants. In addition, we are continuing to follow the cohort for mortality to determine whether previously observed patterns persist.
A retrospective cohort study is also being conducted to examine the effects on cancer risk of different causes of infertility and of different associated therapies. This study involves detailed abstraction of medical records of patients diagnosed as long ago as the 1960's and administration of questionnaires to obtained updated health information. A strength of the study is the detailed information collected on causes of infertility. This hasl enabled analyses related to how specific endocrinologic abnormalities relate to cancer risk. In addition, analyses have been undertaken to determine whether there is a link with ovulation-stimulating drugs. In a separate investigation, conducted in collaboration with investigators in Denmark, cancer risk among children conceived following use of ovulation-stimulating drugs has been assessed. Preliminary analyses show no alteration in childhood cancer risk.
A number of medical conditions have been suggested as predisposing to the risk of breast, endometrial and ovarian cancers, but most of these studies have relied on patients reports of these prior conditions. To obtain more precise information on the nature of these prior medical conditions, we have conducted a large case-cohort study in Denmark that involves access to details of the conditions as contained in medical records. Ongoing analyses are assessing relationships of cancer risk according to details of the prior diagnoses.
这个项目的一个主要重点是确定外源性激素与随后的癌症风险的关系。使用类似的方法来检查外源性激素对乳腺癌风险的影响,在一个大型筛查项目的背景下进行的分析显示,绝经期激素的使用与卵巢癌的风险有关。这些分析表明,使用激素的风险随着使用时间的增加而增加,特别是当使用的制剂是无对抗的雌激素时。与子宫内膜癌的关系正在通过额外的随访数据进行研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LOUISE BRINTON其他文献
LOUISE BRINTON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LOUISE BRINTON', 18)}}的其他基金
Therapeutic and Diagnostic Factors as Related to Cancer Risk
与癌症风险相关的治疗和诊断因素
- 批准号:
8565423 - 财政年份:
- 资助金额:
-- - 项目类别:
THERAPEUTIC AND DIAGNOSTIC FACTORS AS RELATED TO CANCER RISK
与癌症风险相关的治疗和诊断因素
- 批准号:
6289550 - 财政年份:
- 资助金额:
-- - 项目类别:
相似海外基金
Pathology of Breast Neoplasms determined by MRS
MRS 测定乳腺肿瘤的病理学
- 批准号:
nhmrc : 950215 - 财政年份:1995
- 资助金额:
-- - 项目类别:
NHMRC Project Grants