Investigating targeted PDT drugs as herbicidal and anti-microbial agents

研究作为除草剂和抗微生物剂的靶向 PDT 药物

• 批准号: 2443549
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2443549
• 关键词: Investigating; targeted; PDT; drugs; herbicidal

Photodynamic Therapies are beginning to show clinical efficacy, however, application of the technology in non-mammalian species has been limited due to difficulties generating photoactivatable compounds. LightOx has developed novel photochemistry that allows the development of small molecular weight photosensitive chemicals. These compounds can be taken up by bacteria and plant cells and show no toxicity in the absence of irradiation. The mechanism by which PDT kills cells is different from that of conventional antibiotics and herbicides. As the problem of antibiotic and herbicide resistance is on the rise globally, this project aims is to generate evidence on the potential of these compounds to selectively target and destroy antibiotic-resistant microbes and herbicide-resistant weeds. Providing new treatment methods to aid in the fight against these global issues.

光动力疗法开始显示出临床疗效，然而，由于难以产生可光活化的化合物，该技术在非哺乳动物物种中的应用受到限制。LightOx开发了一种新的光化学，可以开发小分子量的光敏化学品。这些化合物可以被细菌和植物细胞吸收，在没有辐射的情况下没有毒性。PDT杀死细胞的机制与传统的抗生素和除草剂不同。随着抗生素和除草剂耐药性问题在全球范围内日益严重，该项目的目的是提供证据，证明这些化合物有可能选择性地靶向和摧毁耐药性微生物和耐除草剂杂草。提供新的治疗方法，以帮助对抗这些全球性问题。