Continuous Manufacturing with Carbon Nanoreactor Supported Nanoparticle Catalysts for the Self-Optimisation of Heterogenous Reduction Reactions

使用碳纳米反应器支持的纳米颗粒催化剂连续制造，用于多相还原反应的自我优化

• 批准号: 2443634
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2443634
• 关键词: Continuous; Manufacturing; Carbon; Nanoreactor; Supported

This industrially sponsored project, between Dr Thomas Chamberlain and Dr Richard Bourne (University of Leeds) and Dr Kevin Leslie and Dr Graeme Clemens (Process Chemistry at AstraZeneca), will enable high throughput, flow hydrogenation at scale enabling robust, continuous manufacture. To achieve this the project will fabricate novel carbon based, pelleted catalyst materials, incorporating an ultra-hard core, proving the structural strength and dimensions required to minimize pressure drop across a flow reactor column, with an innovative, nanoreactor based porous outer shell designed to maximize surface area, nanoparticle stabilization and the rate of reactions. These catalysts will be integrated into the self-optimizing, reactor platform, at Leeds, capable of performing heterogeneous hydrogenation in flow, will enable optimisation of heterogeneously catalysed chemical reactions in flow of exemplar active pharmaceutical ingredient targets determined in partnership with AstraZeneca. This will include a placement at AZ Macclesfield, including training on state-of-the-art continuous flow hydrogenation apparatus and engagement with colleagues in process development.The research and training will include: the construction, validation, and testing of automated reactor platforms, organic synthetic chemistry in flow; heterogeneous catalysts preparation, characterisation and utilisation; analysis of reaction outcomes using a range of techniques and exploitation of self-optimising algorithms. This project will involve flow chemistry and applied catalysis, and in the use of state-of-the-art automated techniques.

这个由Thomas Chamberlain博士和Richard Bourne博士（利兹大学）以及Kevin Leslie博士和Graeme Clemens博士（阿斯利康工艺化学）共同参与的这个工业赞助项目将实现大规模的高通量、流动氢化，从而实现稳健、连续的生产。为了实现这一目标，该项目将制造新型碳基颗粒催化剂材料，结合超硬核心，证明最小化流动反应器柱压降所需的结构强度和尺寸，并采用创新的基于纳米反应器的多孔外壳，旨在最大限度地提高表面积、纳米颗粒稳定性和反应速率。这些催化剂将集成到利兹的自优化反应器平台中，能够在流动中进行非均相氢化，从而能够优化与阿斯利康合作确定的示例性活性药物成分目标流中的非均相催化化学反应。这将包括在 AZ Macclesfield 的实习，包括最先进的连续流动氢化装置的培训以及与同事参与工艺开发。研究和培训将包括：自动化反应器平台的构建、验证和测试、流动有机合成化学；多相催化剂的制备、表征和应用；使用一系列技术和利用自优化算法来分析反应结果。该项目将涉及流动化学和应用催化，并使用最先进的自动化技术。