FASEB Summer Research Conference on Small G-Proteins

FASEB 小 G 蛋白夏季研究会议

• 批准号: 6810077
• 负责人: JEFFREY E SETTLEMAN
• 金额: $ 0.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2005-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6810077
• 关键词: G protein; guanosinetriphosphatases; meeting /conference /symposium; protein structure function; travel

DESCRIPTION (provided by applicant): We would like to request partial funding for a FASEB conference on "Regulation and Function of Small GTPases" to be held on July 10-15 in Snowmass, Colorado. The small GTPase superfamily comprises a group of more than 100 closely related molecular switches that have been highly conserved through evolution, and which appear to regulate numerous cell biological processes. This family includes, among others, the Ras proteins, which have been studied intensively in the context of human oncogenesis, the Rho proteins, that function as key regulators of the cytoskeleton, and the Rab proteins, that are major regulators of vesicle trafficking and secretion. The conference will include presentations from many of the most prominent researchers in each of these fields. The sessions have been organized in such a way as to emphasize the related aspects of biochemical regulation among these distinct family members as well as the emerging theme that there is substantial cross-talk between the various small GTPase-mediated signaling pathways. Thus, an important goal is to promote interactions and potential collaborations among investigators in this field. The small GTPases have been directly implicated in several important human health problems, including cancer, diabetes, and hypertension, and there will be presentations that address the role of these proteins in both normal biology as well as in disease processes. There will be approximately 200 participants in this conference, among which, 44 will be invited speakers. In addition, 8 speakers will be selected for short presentations from a group of submitted abstracts. The conference will cover the biochemical, structural, and functional aspects of the various small GTPases and their regulators and targets.

描述（由申请人提供）：我们想为7月10日至15日在科罗拉多州的雪摩斯举行的有关“小型GTPases的调节和功能”的FaseB会议要求部分资金。 小的GTPase超家族包括一组100多个密切相关的分子开关，这些开关通过进化高度保守，并且似乎调节了许多细胞生物学过程。 该家族包括在人类肿瘤发生的背景下对RAS蛋白进行深入研究的RAS蛋白，该蛋白是Rho蛋白，它们是细胞骨架的关键调节剂，而Rab蛋白是囊泡运输和分泌的主要调节剂。 该会议将包括来自每个领域中许多最杰出的研究人员的演讲。 这些会话的组织方式是强调这些不同的家庭成员之间生化调节的相关方面，以及新兴的主题，即各种小型GTPase介导的信号传导途径之间存在实质性的互相交叉。因此，一个重要的目标是促进该领域研究人员之间的互动和潜在的合作。 小型GTPases已直接与几个重要的人类健康问题有关，包括癌症，糖尿病和高血压，并且将有一些介绍来解决这些蛋白质在正常生物学以及疾病过程中的作用。 这次会议将有大约200名参与者，其中44名将邀请演讲者。 此外，将从一组提交的摘要中选出8位演讲者进行简短的演讲。 该会议将涵盖各种小型GTPases及其调节器和目标的生化，结构和功能方面。