Conference Proposal: Transplantation Immunology

描述(由申请人提供)：这是一个关于“移植免疫学”会议的部分资金申请，该会议将于2004年6月19-24日在科罗拉多州斯诺马斯村举行。这次会议是在2002年在萨克斯顿佛蒙特州河畔成功举办的关于同一主题的首届FASEB夏季研究会议之后举行的。2004年的会议将聚焦于分子和细胞免疫学、干细胞生物学和技术进步方面最重要的最新进展，这些进展与更好地理解移植排斥和耐受性的机制基础有直接关系。同样重要的是，这些发现对于改进细胞和器官移植排斥反应的治疗方法的发展具有重要意义，这可能最终导致临床移植耐受的一致实现。会议的重点将集中在1)T细胞-抗原递呈细胞相互作用；2)T和B细胞记忆；3)自然杀伤细胞和非经典T细胞；4)B细胞耐受性；5)骨髓移植和移植物抗宿主反应性；6)血管和实质炎症的调节；7)干细胞/组织工程和8)新技术/免疫学监测。这次会议的一个重要方面将是具有基础免疫学和分子遗传学/生物学专业知识的科学家与移植科学家和临床医生之间的互动。大约180名参与者将从最有可能分享最新新知识并为促进思想/概念交流做出贡献的调查人员中挑选出来。组织者不断努力将妇女、少数群体和残疾人纳入规划/方案发展的每一步。演讲者和海报主持人将是那些最近做出最重大贡献的人。还将举行两次海报展示会议。会议将提供一个重要的论坛，供来自广泛次级专业的贡献者之间进行对话。汇总的结果应该是对这一快速发展的应用生物医学科学领域的概述和综合观点/共识。一个重要的目标将是对未来研究方向的评估，以及对当代“前沿”研究的批判性评估。

DESCRIPTION (provided by applicant): This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB at Snowmass Village, Colorado June 19-24, 2004. This conference follows the successful inaugural 2002 FASEB Summer Research Conference on the same topic held at Saxton's River Vermont. The 2004 conference will target the most important recent developments in molecular and cellular immunology, stem cell biology and technologic advances that have direct relevance to improved understanding of the mechanistic basis of transplant rejection and tolerance. Equally significant, are the implications of these findings for the development of improved therapies of cell and organ graft rejection, that may lead ultimately, to the consistent achievement of clinical transplantation tolerance. Emphasis will be placed on the most recent insights in sessions that will be devoted to 1) T cell-antigen-presenting cell interactions; 2) T and B cell memory; 3) natural killer cells and non-classical T cells; 4) B cell tolerance; 5) bone marrow transplantation and graft-versus-host reactivity; 6) modulation of vascular and parenchymal inflammation; 7) stem cells/tissue engineering and 8) novel technologies/immunologic monitoring. An important aspect of this conference will be the interaction between scientists with expertise in basic immunology and molecular genetics/biology and transplantation scientists and clinicians. Approximately 180 participants will be selected from amongst those investigators most likely to share the most recent new knowledge, and to contribute to stimulating exchange of ideas/concepts. The organizers have continually strived to include women, minorities and disabled individuals at each step of planning/program development. Speakers and poster presenters will be those who have made the most significant recent contributions. There will also be two poster presentation sessions. The conference will provide an important forum for dialogue between contributors from a broad range of subspecialties. The aggregate result should be an overview and integrated perspective/consensus of this rapidly moving field of applied biomedical science. An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research.