Conference Proposal: Transplantation Immunology

描述（由申请人提供）：这是一份申请“移植免疫学”会议部分资金的申请，该会议将于2004年6月19日至24日在科罗拉多州斯诺马斯村举行，由FASEB主持。本次会议是继2002年FASEB夏季研究会议成功召开之后的又一次会议，该会议在萨克斯顿的佛蒙特河举行，主题相同。2004年会议的目标是分子和细胞免疫学、干细胞生物学和技术进步方面最重要的最新进展，这些进展与提高对移植排斥和耐受的机制基础的理解直接相关。同样重要的是，这些发现对改进细胞和器官移植排斥治疗的发展具有重要意义，这可能最终导致临床移植耐受的一致实现。重点将放在会议的最新见解，将致力于1)T细胞-抗原呈递细胞相互作用；2) T细胞和B细胞记忆；3)自然杀伤细胞和非经典T细胞；4) B细胞耐受性；5)骨髓移植和移植物抗宿主反应；6)血管和实质炎症的调节；7)干细胞/组织工程和8)新技术/免疫监测。本次会议的一个重要方面将是具有基础免疫学和分子遗传学/生物学专业知识的科学家与移植科学家和临床医生之间的互动。大约180名参与者将从那些最有可能分享最新新知识，并有助于促进思想/概念交流的研究人员中选出。组织者不断努力将妇女、少数民族和残疾人纳入规划/项目开发的每一步。演讲者和海报展示者将是那些最近做出最重要贡献的人。还将有两个海报展示环节。会议将为来自广泛的分专业的贡献者之间的对话提供一个重要的论坛。总体结果应该是对这一快速发展的应用生物医学科学领域的概述和综合观点/共识。一个重要的目标是评估未来的研究方向，以及对当代“前沿”研究的批判性评价。

DESCRIPTION (provided by applicant): This is an application for partial funding of a conference on "Transplantation Immunology" that will be held under the auspices of FASEB at Snowmass Village, Colorado June 19-24, 2004. This conference follows the successful inaugural 2002 FASEB Summer Research Conference on the same topic held at Saxton's River Vermont. The 2004 conference will target the most important recent developments in molecular and cellular immunology, stem cell biology and technologic advances that have direct relevance to improved understanding of the mechanistic basis of transplant rejection and tolerance. Equally significant, are the implications of these findings for the development of improved therapies of cell and organ graft rejection, that may lead ultimately, to the consistent achievement of clinical transplantation tolerance. Emphasis will be placed on the most recent insights in sessions that will be devoted to 1) T cell-antigen-presenting cell interactions; 2) T and B cell memory; 3) natural killer cells and non-classical T cells; 4) B cell tolerance; 5) bone marrow transplantation and graft-versus-host reactivity; 6) modulation of vascular and parenchymal inflammation; 7) stem cells/tissue engineering and 8) novel technologies/immunologic monitoring. An important aspect of this conference will be the interaction between scientists with expertise in basic immunology and molecular genetics/biology and transplantation scientists and clinicians. Approximately 180 participants will be selected from amongst those investigators most likely to share the most recent new knowledge, and to contribute to stimulating exchange of ideas/concepts. The organizers have continually strived to include women, minorities and disabled individuals at each step of planning/program development. Speakers and poster presenters will be those who have made the most significant recent contributions. There will also be two poster presentation sessions. The conference will provide an important forum for dialogue between contributors from a broad range of subspecialties. The aggregate result should be an overview and integrated perspective/consensus of this rapidly moving field of applied biomedical science. An important goal will be evaluation of future research directions, as well as critical appraisal of contemporary "cutting edge" research.