Eighth International Workshop on Radiation Damage to DNA

描述(由申请者提供)：“辐射对DNA的损害”国际研讨会将介绍在理解DNA中的辐射能量沉积通过DNA中的化学和生物化学变化引发的途径以及DNA损伤的最终生物学后果方面的最新进展。这是一系列研讨会中的第八个，这些研讨会聚集了辐射物理学家、化学家和生物学家，以高度互动的多学科形式讨论辐射对DNA的损害。研讨会将于2004年5月25日至30日在加拿大班夫的班夫会议中心举行。参加人数限制在105人以内。与会者将来自世界各地的学术和研究机构，包括研究生、博士后研究员、职业生涯中期和高级科学家。 会议将讨论的议题包括：瞬时DNA自由基，辐射DNA中碱基/核苷末端产物的识别和测量，径迹结构，簇状损伤，DNA中的电荷/能量转移，高LET效应，低能量辐射的反应，染色质结构在DNA损伤诱导和修复中的作用，辐射足迹，受损DNA碱基的结构和识别它们的蛋白质，DNA碱基损伤的修复，辐射诱导的链断裂末端，DNA双链断裂的修复，突变诱导，以及未修复的DNA损伤的其他生物学后果。 这次会议的一个重要目标是减少学科上的两极分化，并鼓励科学家进行新的跨学科思维和实验方法，因为他们意识到其他领域的发现与他们自己工作的相关性。虽然重点跨越物理、化学和生物，但所有参与者的共同目标是增加对生物终点的理解，即在可预测的物理事件和辐射DNA中发生的化学变化方面。为此，将大力推动所有学科之间的共同语言，目的是促进不同研究领域的个人之间的交流和研究互动。

DESCRIPTION (provided by applicant): The International Workshop on "Radiation Damage to DNA" will cover recent advances in the understanding of the pathways initiated by radiation energy deposition in DNA through the chemical and biochemical changes in the DNA to the ultimate biological consequences of the DNA lesions. This the eighth in a series of workshops that bring together radiation physicists, chemists and biologists to discuss radiation damage to DNA in a highly interactive, multidisciplinary format. The workshop will be held May 25-30, 2004 at the Banff Conference Centre in Banff, Canada. The number of participants is limited to 105. The participants will be from academic and research institutions world-wide and will include graduate students, post-doctoral fellows, and mid-career and senior scientists. The topics that will be covered at the meeting include transient DNA radicals, identification and measurement of base/nucleoside end products in irradiated DNA, track structure, clustered damage, charge/energy transfer in DNA, high LET effects, reactions of low energy radiations, role of chromatin structure in DNA damage induction and repair, radiolytic footprinting, structure of damaged DNA bases and the proteins that recognize them, repair of DNA base damage, radiation-induced strand break termini, repair of DNA double strand breaks, mutation induction, and other biological consequences of unrepaired DNA damage. An important goal of this meeting is to decrease polarization by discipline and stimulate new, interdisciplinary thinking and experimental approaches by scientists who become aware of the relevance of findings from other fields to their own work. Although the focus spans physics, chemistry and biology, the common goal of all the participants is to increase understanding of the biological endpoints in terms of predictable physical events and chemical alterations that occur in irradiated DNA. To this end, a strong effort will be made to work on a common language between all the disciplines, with the objective of facilitating communications and research interactions among individuals in the various research areas.