Expanding the repertoire of immunomodulatory drugs: targeting the melanocortin system using engineered cyclic peptides

扩大免疫调节药物的范围：使用工程环肽靶向黑皮质素系统

• 批准号: nhmrc : GNT1120066
• 负责人: Dr Simon de Veer
• 金额: $ 31.88万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/expanding-repertoire-immunomodulatory-cyclic-peptides/1347097
• 关键词: Expanding; repertoire; immunomodulatory; drugs; targeting

Autoimmune diseases, including rheumatoid arthritis and psoriasis, have profound impacts on the lives of many Australians. New drugs are required for these diseases as existing treatments are expensive, become less effective with repeated use or cause adverse side effects. My project will work towards addressing this need by investigating the potential of ultrastable cyclic miniproteins as scaffolds for displaying bioactive peptides that are known to restore immune self-tolerance.

自身免疫性疾病，包括类风湿性关节炎和牛皮癣，对许多澳大利亚人的生活产生深远影响。这些疾病需要新的药物，因为现有的治疗方法昂贵，重复使用或导致不良副作用而变得不那么有效。我的项目将致力于解决这一需求，通过研究超稳定环状微蛋白作为支架的潜力，用于展示已知可恢复免疫自我耐受的生物活性肽。