Expanding the repertoire of immunomodulatory drugs: targeting the melanocortin system using engineered cyclic peptides

扩大免疫调节药物的范围：使用工程环肽靶向黑皮质素系统

• 批准号: nhmrc : 1120066
• 金额: $ 21.75万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/expanding-repertoire-immunomodulatory-cyclic-peptides/946423
• 关键词: Expanding; repertoire; immunomodulatory; drugs; targeting

Autoimmune diseases, including rheumatoid arthritis and psoriasis, have profound impacts on the lives of many Australians. New drugs are required for these diseases as existing treatments are expensive, become less effective with repeated use or cause adverse side effects. My project will work towards addressing this need by investigating the potential of ultrastable cyclic miniproteins as scaffolds for displaying bioactive peptides that are known to restore immune self-tolerance.

自身免疫性疾病，包括类风湿性关节炎和牛皮癣，对许多澳大利亚人的生活有深远的影响。这些疾病需要新药，因为现有的治疗方法昂贵，重复使用会变得不那么有效，或者会产生不良副作用。我的项目将致力于通过研究超稳定的环状微小蛋白作为支架展示生物活性多肽的潜力来满足这一需求，这些生物活性多肽已知可以恢复免疫自我耐受。