Neural Mechanisms of Motion Sensitivity in V1 and MT

V1 和 MT 运动敏感性的神经机制

• 批准号: 6943200
• 负责人: Luis Andres Lesmes
• 金额: $ 4.21万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-16 至 2008-03-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943200
• 关键词: Macaca mulatta; behavioral /social science research tag; brain mapping; color visions; computational neuroscience; electrophysiology; eye movements; information display; magnetic resonance imaging; microelectrodes; motion perception; neurons; neurophysiology; photostimulus; postdoctoral investigator; psychophysics; visual cortex; visual perception

DESCRIPTION (provided by applicant): A formal theory of motion systems, distinguishing the contributions of three independent motion mechanisms to human motion perception, is applied to neurophysiology. This framework is applied to investigate the neural mechanisms underlying sensitivity to drifting luminance, texture, and color in the visual cortices of awake, behaving primates. The elucidation of neural mechanisms, based on sensitivity measured to different motion stimuli, is made difficult by motion integration and stimulus distortions, factors obscuring basic properties of motion mechanisms, such as the motion computation's locus, algorithm and relationship to other mechanisms. The proposed work addresses these issues by (1) identifying and removing aberrant luminance motion signals from drifting texture and color, (2) identifying the motion algorithms, (motionenergy vs. feature-based), underlying neural sensitivity, and (3) distinguishing the contributions of motion computation and motion integration to neural sensitivity. Decomposing neural sensitivity to luminance, texture, and chromatic motion, using a framework developed to distinguish mechanisms of motion perception, may similarly distinguish mechanisms underlying neural motion sensitivity in primates.

描述（由申请人提供）：运动系统的正式理论，区分三个独立的运动机制对人类运动感知的贡献，应用于神经生理学。这个框架是适用于调查的神经机制，潜在的敏感性漂移亮度，纹理和颜色在清醒的，行为灵长类动物的视觉皮层。基于对不同运动刺激测量的敏感性的神经机制的阐明由于运动整合和刺激失真而变得困难，这些因素模糊了运动机制的基本属性，例如运动计算的轨迹、算法以及与其他机制的关系。所提出的工作通过以下方式解决这些问题：（1）从漂移的纹理和颜色中识别和去除异常亮度运动信号;（2）识别运动算法（motionenergy与基于特征的），潜在的神经敏感性;以及（3）区分运动计算和运动集成对神经敏感性的贡献。分解神经灵敏度的亮度，纹理，和彩色运动，使用开发的框架来区分运动感知的机制，可以类似地区分灵长类动物的神经运动敏感性的机制。