Characterization of monoallelic regulation variation and aneuploidy associated dosage compensation mechanisms in human pre-implantation embryos
Characterization of monoallelic regulation variation and aneuploidy associated dosage compensation mechanisms in human pre-implantation embryos
人类植入前胚胎中单等位基因调控变异和非整倍性相关剂量补偿机制的表征
批准号：
2444828
负责人：
金额：
$0.0万
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
项目状态：
未结题
起止时间：
2020 至 --
中文摘要
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英文摘要
We are developing and applying computational and experimental methods to help decipher the underlying reason why some human embryos undergo spontaneous developmental arrest. Using cutting-edge single-cell (epi)genomic and transcriptomic tools, we hope to provide new insights into the establishment of monoallelic gene regulation (genomic imprinting, X-inactivation and eQTLs) in mediating embryo development and in utero growth.
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