Investigating the function and regulation of IFITM proteins in interferon biology and disease

研究 IFITM 蛋白在干扰素生物学和疾病中的功能和调节

• 批准号: 2445111
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2445111
• 关键词: Investigating; function; regulation; IFITM; proteins

The Interferon Induced Transmembrane (IFITM) gene family consists of three anti-viral restriction factors, IFITM1-3. Studies starting in 2009 demonstrated that these proteins have critical and broad-spectrum protective activities in a variety of infection models, acting at the level of viral entry by preventing capsid fusion. Research from the laboratories of Richard Sloan and Kathryn Ball however have revealed novel functions for these proteins. The Sloan lab has shown that IFITM proteins inhibit intracellular HIV1 virus production independently of the viral entry step by inhibiting viral protein translation. The Ball lab have also independently discovered a role for IFITM1 and IFITM3 in regulating interferon-induced cellular protein synthesis. My goal is to clarify this new aspect of IFITM biology, detail how it is regulated by post-translational modification, and study implications for disease scenarios.

干扰素诱导跨膜（IFITM）基因家族由三个抗病毒限制因子IFITM1-3组成。2009年开始的研究表明，这些蛋白在各种感染模型中具有关键的广谱保护活性，通过阻止衣壳融合在病毒进入水平起作用。然而，Richard Sloan和Kathryn Ball实验室的研究揭示了这些蛋白质的新功能。斯隆实验室已经证明，IFITM蛋白通过抑制病毒蛋白翻译，独立于病毒进入步骤抑制细胞内hiv病毒的产生。Ball实验室还独立发现IFITM1和IFITM3在调节干扰素诱导的细胞蛋白合成中的作用。我的目标是阐明IFITM生物学的这一新方面，详细说明它是如何被翻译后修饰调节的，并研究其对疾病情景的影响。