Exploiting messenger RNA export as a novel therapeutic strategy to treat cancer

癌症的新疗法代表着一个尚未得到满足的临床需求领域。我们发现了与癌症有关的一种新的生物学途径，即选择性的信使核糖核酸输出。抑制基因表达途径其他步骤的化合物是治疗癌症的有希望的候选药物，但还不存在信使核糖核酸输出抑制剂。我们建议开发一流的mRNA输出抑制剂，通过失调的RNA加工选择性地靶向转录成瘾的癌症。

Novel therapies for cancers represent an area of unmet clinical need. We have identified a new biological pathway implicated in cancer, namely selective mRNA export. Compounds inhibiting other steps of the gene expression pathway are promising therapeutic candidates for cancer, yet mRNA export inhibitors do not exist. We propose to develop first-in-class inhibitors of mRNA export that selectively target transcriptionally addicted cancers with dysregulated RNA processing.