Investigation of the effect of host genetic variants on subgingival microbes and gingival inflammation in gingivitis and periodontitis.

研究宿主遗传变异对牙龈炎和牙周炎中龈下微生物和牙龈炎症的影响。

• 批准号: 2446659
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2446659
• 关键词: Investigation; effect; host; genetic; variants

Micronutrients such as manganese, iron, copper, and zinc are essential for healthy skin. Although skin contains mainly keratinocytes, about a tenth of the cells are specialized: e.g. melanocytes, Langerhans cells or inflammatory cells. Langerhans cells form tight junctions with keratinocytes, are absent under zinc deficiency, and together with the stratum corneum are important for epidermal barrier function. The relative significance of these metal ions for the different cell types is unknown. Major advances in mass spectrometric techniques now allow imaging the distribution of metal ions in tissues and cells. It established that metal ions are not randomly distributed but rather follow cell-specific functions. For different skin cells such metal profiles are essentially unknown. Metal ions are involved in lipid biosynthesis, which is of direct relevance to processes such as barrier disruption in ageing skin or dandruff in scalp.

锰、铁、铜和锌等微量营养素对健康的皮肤至关重要。虽然皮肤主要含有角质形成细胞，但约十分之一的细胞是特化的：例如黑素细胞、朗格汉斯细胞或炎性细胞。朗格汉斯细胞与角质形成细胞形成紧密连接，在锌缺乏时不存在，并且与角质层一起对于表皮屏障功能是重要的。这些金属离子对不同细胞类型的相对重要性尚不清楚。质谱技术的重大进展现在允许成像金属离子在组织和细胞中的分布。它确定了金属离子不是随机分布的，而是遵循细胞特异性功能。对于不同的皮肤细胞来说，这种金属轮廓基本上是未知的。金属离子参与脂质生物合成，这与诸如老化皮肤中的屏障破坏或头皮中的头皮屑等过程直接相关。