Role of cytidine deaminase in (epi)genetic adaptation of the plant immune system

胞苷脱氨酶在植物免疫系统（表观）遗传适应中的作用

• 批准号: 2449363
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449363
• 关键词: Role; cytidine; deaminase; epi; genetic

As sessile organisms, plants are masters in adapting to environmental stresses. Recent work from the Ton lab has shown that plants employ epigenetic mechanisms to prime their immune system long-term against potential pests and diseases. This PhD project will study the interplay between epigenetic and genetic mechanisms controlling expression and diversification of resistance (R) genes in the model plant species Arabidopsis thaliana. In particular, the project will focus on the role of the Arabidopsis cytidine deaminase CDA1 in the modulation of epigenetic marks and its impact on genetic diversity. The student will use state-of-the art genetic and molecular techniques, and work in a highly dynamic lab that combines fundamental research with translational research to develop new technologies that benefit sustainable crop protection.

植物作为固着生物，是适应环境胁迫的能手。TON实验室最近的研究表明，植物利用表观遗传机制为其免疫系统做好长期准备，以抵御潜在的害虫和疾病。这个博士项目将研究表观遗传和遗传机制之间的相互作用，这些机制控制着模式植物拟南芥中抗性(R)基因的表达和多样化。特别是，该项目将侧重于拟南芥胞苷脱氨酶CDA1在表观遗传标记调控中的作用及其对遗传多样性的影响。学生将使用最先进的基因和分子技术，并在一个高度活跃的实验室工作，该实验室将基础研究与转化研究相结合，开发有利于可持续作物保护的新技术。