The Conformational Dynamics of Two-Way DNA Junctions: A common first step in aberrant DNA recognition?

双向 DNA 连接的构象动力学：异常 DNA 识别的常见第一步？

• 批准号: 2449456
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449456
• 关键词: Conformational; Dynamics; Two; Way; DNA

study of the conformational dynamics of aberrant DNAs. Experimental data from single-molecule FRET, fluorescent lifetimes spectroscopy, and other biophysical techniques, will be combined with molecular dynamic simulations (with Kresten Lindorff-Larsen in Copenhagen) to produce the most detailed view of aberrant DNA conformational dynamics to date. This multidisciplinary approach will help us understand the first step in aberrant DNA detection.The successful student will join a vibrant and world-leading research grouping within the Krebs Institute for Mechanistic Biology and Imagine: Imaging Life, developing skills in cutting-edge single-molecule and ultrafast spectroscopy, and molecular modelling, with opportunities for industrial engagement as the project progresses.

研究异常DNA的构象动力学。来自单分子FRET，荧光寿命光谱和其他生物物理技术的实验数据将与分子动力学模拟（与哥本哈根的Kresten Lindorff Larsen合作）相结合，以产生迄今为止异常DNA构象动力学的最详细视图。这一跨学科的方法将帮助我们理解异常DNA检测的第一步。成功的学生将加入克雷布斯机械生物学研究所内一个充满活力和世界领先的研究小组，并想象：成像生命，发展尖端单分子和超快光谱学以及分子建模方面的技能，随着项目的进展，有机会参与工业活动。