INFUCE -Inhibitors of fungal B-glucan cell wall biosynthesis via assay-based compound screening

INFUCE - 通过基于测定的化合物筛选真菌 B-葡聚糖细胞壁生物合成的抑制剂

• 批准号: 2449869
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2449869
• 关键词: INFUCE; Inhibitors; fungal; glucan; cell

The aim of the project INFUCE is to establish biochemical assays based on existing preliminary protein data to improve understanding of the mechanisms of fungal cell wall biosynthesis. The project will incorporate transformative technologies that enable integration of physical and life sciences approaches in fungal cell wall tracking, mainly through development of STORMForce applications that combine methods for atomic force microscopy (AFM) and super-resolution optics (STORM) in molecular scale imaging and correlative optical microscopy. The data generated will then be extended to translation of biochemical assays for industrial requirements using research and test facilities both in Sheffield and at the Jealott's Hill International Research Centre in Bracknell, UK.

INFUCE项目的目的是根据现有的初步蛋白质数据建立生物化学测定，以提高对真菌细胞壁生物合成机制的理解。该项目将采用变革性技术，将物理和生命科学方法整合到真菌细胞壁跟踪中，主要通过开发STORMForce应用程序，将原子力显微镜（AFM）和超分辨率光学（STORM）方法结合在分子尺度成像和相关光学显微镜中。然后，所产生的数据将被扩展到使用谢菲尔德和英国布拉克内尔的Jealott's Hill国际研究中心的研究和测试设施的工业要求的生化分析的翻译。