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Optical Control in a Single-molecule Electrochemical Sensor

单分子电化学传感器中的光学控制

基本信息

批准号：
2453527
负责人：
金额：
--
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2453527
关键词：
Optical Control Single molecule Electrochemical

项目摘要

Single-molecule detection technique provides a powerful platform for scientists to observe biomolecular function that is difficult to sense using conventional techniques. Quantum tunnelling, combined with biosensors has raised broad interests recently due to its advantages in high spatial resolution and sensitivity. However, it is still challenging to controllably fabricate a tunnelling device with ease and low cost. This project aims to develop a novel method for fabrication of tunnelling device by electrochemical feedback-control deposition of platinum. Such electrochemically fabricated tunnelling junctions will likely have extended long term stability and will be ideally suited for continuous monitoring in complex samples. Single-molecule techniques have attracted great attention because of their ability to conduct studies of molecules at the nanoscale. Tunnelling sensors are a class of single-molecule detection techniques that possess extremely high spatial resolution and sensitivity. However, an obstacle during detection is the poor temporal resolution. One promising route to overcome this challenge is to combine ultrafast spectroscopy with tunnelling detection. In this project, the combination of electrochemical deposition and electromigration breakdown is applied to fabricate a new type of tunnelling sensors that are based on dual-barrel nanopipettes.

单分子检测技术为科学家提供了一个强大的平台，以观察生物分子的功能，是很难用传统的技术。量子隧穿技术与生物传感器相结合，由于具有高空间分辨率和灵敏度的优点，近年来引起了人们的广泛关注。然而，容易且低成本地可控地制造隧穿装置仍然是具有挑战性的。本计画旨在发展一种利用电化学回馈控制沉积铂来制作隧穿元件的新方法。这种电化学制造的隧道结将可能具有延长的长期稳定性，并且将理想地适合于复杂样品中的连续监测。单分子技术由于其在纳米尺度上进行分子研究的能力而引起了极大的关注。隧道传感器是一类具有极高空间分辨率和灵敏度的单分子检测技术。然而，在检测期间的障碍是差的时间分辨率。克服这一挑战的一个有希望的途径是将联合收割机超快光谱与隧道探测相结合。在这个项目中，电化学沉积和电迁移击穿的组合被应用于制造一种新型的隧道传感器，是基于双筒纳米移液管。