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Building an Autonomous Chemically-Fuelled Rotary Molecular Motor

建造自主化学燃料旋转分子马达

基本信息

批准号：
2455398
负责人：
金额：
--
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2455398
关键词：
Building Autonomous Chemically Fuelled Rotary

项目摘要

Chemically fuelled molecular motors are ubiquitous in nature, autonomously converting energy into work or motion to power biological processes. Synthetic molecular motors hold potential as components in future nanoscale technologies,1 however autonomy remains a challenging aspect of molecular motion to achieve. To date, only one artificial chemically-fuelled motor with this feature has been reported, based on a catenane architecture.2 In this project, we aim to develop biaryl motors capable of unidirectional chemically-fuelled autonomous rotary motion around a single bond. Key to developing an autonomous motor will be the exploration of cyclical chemical reaction networks (CRNs), that is, systems in which opposing, non-microscopically reversible reactions occur concurrently, resulting in the repeated chemical transformation of substrates between two or more states3. It is hoped that, in addition to creating a system capable of autonomous motion, the synthetic simplicity of the proposed motors will make developing applications for these molecular machines more accessible in future. This project will employ synthetic organic chemistry to access the substrates necessary for the development of these chemical reaction networks, as well as a variety of analytical techniques such as NMR labelling and kinetics studies to analyse the dynamic non-equilibrium behaviour of the system and prove continuous rotary motion. Erbas-Cakmak, S.; Leigh, D. A.; McTernan, C. T.; Nussbaumer, A. L., Artificial Molecular Machines. Chem. Rev. 2015, 115 (18), 10081-10206. Wilson, M. R.; Solà, J.; Carlone, A.; Goldup, S. M.; Lebrasseur, N.; Leigh, D. A., Nature 2016, 534 (7606), 235-240. Riess, B.; Grötsch, R. K.; Boekhoven, J., Chem 2020, 6 (3), 552-578.

化学燃料分子发动机在自然界中无处不在，自动将能量转化为功或运动，为生物过程提供动力。合成分子发动机作为未来纳米级技术的组件具有潜力，但自主性仍然是实现分子运动的一个具有挑战性的方面。到目前为止，只有一个人工化学燃料发动机具有这种功能，已被报道，基于catenane架构。2在这个项目中，我们的目标是开发联芳基发动机能够单向化学燃料自主旋转运动周围的单键。开发自主电机的关键是探索循环化学反应网络（CRN），即同时发生相反的非微观可逆反应的系统，导致两个或多个状态之间的底物重复化学转化。希望除了创造一个能够自主运动的系统之外，所提出的马达的合成简单性将使这些分子机器的开发应用在未来更容易实现。该项目将采用合成有机化学来获取开发这些化学反应网络所需的底物，以及各种分析技术，如NMR标记和动力学研究，以分析系统的动态非平衡行为并证明连续旋转运动。 Erbas-Cakmak，S.;利，D。一、McTernan角T.; Nussbaumer，A. L.，人工分子机器2015，115（18），10081-10206中。威尔逊，M。的R.; Solà，J.; Carlone，A.; Goldup，S. M.; Lebrasseur，N.;利，D。一、Nature 2016，534（7606），235-240.里斯，B;格勒奇河K.; Boekhoven，J.，Chem 2020，6（3），552-578.