Exploring non-canonical roles for the ribosomal RNA genes critical for malignant transformation and cell fate

探索对恶性转化和细胞命运至关重要的核糖体 RNA 基因的非典型作用

• 批准号: nhmrc : 2002741
• 金额: $ 197.27万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/exploring-non-canonical-cell-fate/1779981
• 关键词: Exploring; non; canonical; roles; ribosomal

Genes are encoded by linear DNA sequences, and whether they are expressed or silenced will depend on modifications and 3D interactions with other genomic regions. We aim to identify genes that interact with the a subnuclear body called the nucleolus during cancer development and differentiation. Understanding how these 3D genomic interactions are altered for the coordinated expression of a suite of genes may provide the basis for novel strategies to manipulate gene expression in disease.

基因由线性DNA序列编码，它们是表达还是沉默取决于修饰和与其他基因组区域的3D相互作用。我们的目标是确定在癌症发展和分化过程中与称为核仁的亚核体相互作用的基因。了解这些3D基因组相互作用是如何改变一套基因的协调表达的，可能为操纵疾病中基因表达的新策略提供基础。