Exploring non-canonical roles for the ribosomal RNA genes critical for malignant transformation and cell fate

基因是由线性DNA序列编码的，它们是否表达或沉默将取决于修饰和与其他基因组区域的三维相互作用。我们的目标是鉴定在癌症发展和分化过程中与称为核仁的亚核体相互作用的基因。了解这些三维基因组相互作用如何改变一组基因的协调表达，可能为在疾病中操纵基因表达的新策略提供基础。

Genes are encoded by linear DNA sequences, and whether they are expressed or silenced will depend on modifications and 3D interactions with other genomic regions. We aim to identify genes that interact with the a subnuclear body called the nucleolus during cancer development and differentiation. Understanding how these 3D genomic interactions are altered for the coordinated expression of a suite of genes may provide the basis for novel strategies to manipulate gene expression in disease.