Exploring the role of nitrogen metabolism, energy metabolism and mitochondrial function in the pathophysiological mechanisms of paediatric ME/CFS.

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease diagnosed by symptoms. Our extensive research has led to a hypothesis that ME/CFS results from toxic by-products of energy production in their cells. This problem can be caused by many unique ways, which could explain the diversity of the ME/CFS patient population. We propose to test this hypothesis with a novel personalised experimental design to simultaneously produce a plethora of new knowledge for the field of ME/CFS.