Exploring the role of nitrogen metabolism, energy metabolism and mitochondrial function in the pathophysiological mechanisms of paediatric ME/CFS.

探讨氮代谢、能量代谢和线粒体功能在儿科 ME/CFS 病理生理机制中的作用。

• 批准号: nhmrc : 1200292
• 金额: $ 78.41万
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls for Research
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-role-nitrogen-paediatric-mecfs/1779558
• 关键词: Exploring; role; nitrogen; metabolism; energy

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease diagnosed by symptoms. Our extensive research has led to a hypothesis that ME/CFS results from toxic by-products of energy production in their cells. This problem can be caused by many unique ways, which could explain the diversity of the ME/CFS patient population. We propose to test this hypothesis with a novel personalised experimental design to simultaneously produce a plethora of new knowledge for the field of ME/CFS.

肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种通过症状诊断的疾病。我们广泛的研究导致了一个假设，即ME/CFS是由细胞中能量生产的有毒副产品引起的。这个问题可能由许多独特的方式引起，这可以解释ME/CFS患者人群的多样性。我们建议用一种新颖的个性化实验设计来测试这一假设，同时为ME/CFS领域提供大量的新知识。