Core-Behavioral Testing

脊髓损伤测试范式：采用21分Basso、Beattie和Bresna han(BBB)运动恢复量表，在野外行走时评估总体运动技能。水平梯子(哥伦布仪器)将用于检查后肢运动功能和肢体间协调。地面运动的具体运动学和运动学参数将使用前面描述的跑道装置进行研究和分析(Muir等人。1996年；Muir and Whishaw 1999)。为了评估动物的感觉功能，将使用冯·弗雷毛发测试触觉和哈格里夫斯的伤害感测试(Stoelting Instruments)。握力测量仪(TSE Systems)是一种新近开发的仪器，可以测量大鼠或小鼠的前爪或后爪的握力。为了研究自主神经反射障碍模型中血压和心率的变化，还需要血压监测仪(哥伦布仪器)。脑损伤测试范例：Morris水迷宫是一种被广泛接受的研究脑损伤后功能缺陷和功能恢复的方法，核心部分将专门设置一个房间。动物还将接受其他范例的测试，包括转杆测试(哥伦布仪器)、平衡木和握力测试仪。

SCI Testing Paradigms: Gross locomotor skill will be assessed during open field walking with the 21-point Basso, Beattie and Bresnahan (BBB) locomotor recovery scale. The horizontal ladder (Columbus Instruments) will be used to examine hindlimb locomotor function and interlimb coordination. Specific kinetic and kinematic parameters of overground locomotion will be studied and analyzed using a runway device previously described (Muir et al. 1996; Muir and Whishaw 1999). For assessment of sensory function animals will be examined using von Frey hairs for testing tactile sensation and Hargreaves' test for nociception (Stoelting Instruments). The grip strength meter (TSE Systems) is a recently developed apparatus that measures the gripping strength of the front or hind paw of either rats or mice. Blood pressure monitors (Columbus Instruments) will also be required in order to study changes in blood pressure and heart rate in a model of autonomic dysreflexia. TBI Testing Paradigms: The Morris water maze is a well accepted procedure for studying functional deficits and recovery of function following TBI and one room of the Core will be dedicated. Animals will also be tested on additional paradigms including the rotarod test (Columbus Instruments), balance beam, and the grip strength meter.