Core-Behavioral Testing

脊髓损伤测试范式：采用21分Basso， Beattie和Bresnahan （BBB）运动恢复量表评估大肌肉运动技能。水平梯（哥伦布仪器）将用于检查后肢运动功能和肢间协调。地面运动的具体动力学和运动学参数将使用前面描述的跑道装置进行研究和分析（Muir et al. 1996; Muir and Whishaw 1999）。为了评估动物的感觉功能，将使用von Frey毛发来测试触觉和Hargreaves伤害感觉测试（Stoelting仪器）。握力计（TSE系统）是一种新开发的仪器，用于测量大鼠或小鼠前爪或后爪的握力。为了在自主神经反射障碍模型中研究血压和心率的变化，还需要血压监测器（哥伦布仪器）。TBI测试范例：Morris水迷宫是一种被广泛接受的方法，用于研究TBI后的功能缺陷和功能恢复，Core将专门用于一个房间。动物还将接受额外的范式测试，包括旋转杆测试（哥伦布仪器）、平衡木和握力计。

SCI Testing Paradigms: Gross locomotor skill will be assessed during open field walking with the 21-point Basso, Beattie and Bresnahan (BBB) locomotor recovery scale. The horizontal ladder (Columbus Instruments) will be used to examine hindlimb locomotor function and interlimb coordination. Specific kinetic and kinematic parameters of overground locomotion will be studied and analyzed using a runway device previously described (Muir et al. 1996; Muir and Whishaw 1999). For assessment of sensory function animals will be examined using von Frey hairs for testing tactile sensation and Hargreaves' test for nociception (Stoelting Instruments). The grip strength meter (TSE Systems) is a recently developed apparatus that measures the gripping strength of the front or hind paw of either rats or mice. Blood pressure monitors (Columbus Instruments) will also be required in order to study changes in blood pressure and heart rate in a model of autonomic dysreflexia. TBI Testing Paradigms: The Morris water maze is a well accepted procedure for studying functional deficits and recovery of function following TBI and one room of the Core will be dedicated. Animals will also be tested on additional paradigms including the rotarod test (Columbus Instruments), balance beam, and the grip strength meter.