Dispositional Affect, Family Environment, Adolescent Sui

描述（由申请人提供）：这个指导以病人为导向的研究职业发展奖（K-23）的应用程序是为了支持博士严的发展作为一个独立的研究科学家与研究的程序线，检查自杀行为的现象。Yen博士寻求进一步的培训，以应用她以前与成人边缘型人格障碍（BPD）患者的临床和研究经验，与青少年一起工作。BPD是重复自杀企图和自杀死亡的一个重要危险因素，但目前还没有关于青少年自杀未遂者BPD的前瞻性研究。本研究旨在探讨情感特质与BPD、家庭功能和青少年自杀倾向之间的关系。为了促进她的职业目标，严博士提出了一个培训计划，包括：1）由青少年自杀，人格障碍和前瞻性研究的专家团队提供指导和临床监督; 2）完成正式的课程，研讨会和讲习班; 3）参与布朗大学医学院的相关，正在进行的项目;以及4）实施拟议的研究项目。这一计划将使她能够增加她的青少年发展和精神病理学的概念知识，获得更多的培训，在评估和治疗的青少年，并进一步发展她的研究设计和数据分析的技能。Yen博士建议检查一个模型，深受Linehan的BPD生物社会理论和著名的发展理论的影响，其中个人性格因素（情感处理与BPD一致）和环境因素（无效的家庭环境）的组合被假设为预测青少年自杀行为（意念和企图）。本研究将以一自然主义的描述性研究，对120名因自杀行为住院的青少年进行为期6个月的追踪研究。将通过6个月间隔内的4次评估获得关键预测因子和结局变量的每周或每月评级，以进行时变分析。这项拟议的研究将解决知识上的一个重大差距，因为它将是第一项研究BPD特征的前瞻性研究，也是第一项研究动态地研究自杀青少年的关键预测变量。

DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award (K-23) application is to support Dr. Yen's development as an independent research scientist with a programmatic line of research that examines the phenomenology of suicidal behaviors. Dr. Yen seeks further training to apply her previous clinical and research experiences with adult borderline personality disorder (BPD) patients, to work with adolescents. BPD represents a significant risk factor for repeat suicide attempts and suicide deaths, yet there has been no prospective study of BPD among adolescent suicide attempters. The proposed study seeks to examine the associations between affective traits consistent with BPD, family functioning, and adolescent suicidality. To facilitate her career goals, Dr. Yen proposes a training plan which consists of: 1) mentorship and clinical supervision provided by a team of experts in adolescent suicidality, personality disorders, and prospective studies; 2) completion of formal coursework, seminars, and workshops; 3) participation in relevant, ongoing projects at Brown University Medical School; and 4) implementation of the proposed research project. This plan will enable her to increase her conceptual knowledge of adolescent development and psychopathology, obtain additional training in assessment and treatment of adolescents, and further develop her skills in research design and data analyses. Dr. Yen proposes to examine a model, heavily influenced by Linehan's biosocial theory of BPD and by prominent developmental theories, in which the combination of individual dispositional factors (affective processing consistent with BPD) and environmental factors (invalidating family environment) is hypothesized to predict adolescent suicidal behavior (ideation and attempts). A naturalistic, descriptive, 6-month follow-up study of 120 adolescents after being hospitalized for suicidal behavior will be implemented to examine this model. Weekly or monthly ratings on key predictor and outcome variables will be obtained via four assessments over the 6-month interval to allow for time-varying analyses. The proposed study would address a significant gap in knowledge, as it would be the first prospective study to examine BPD traits as well as the first study to examine key predictor variables dynamically, in suicidal adolescents.