Neurological Diseases Research in High Risk Newborns

高危新生儿的神经系统疾病研究

基本信息

项目摘要

DESCRIPTION (provided by applicant): This proposal is designed to prepare Dr. Nehal Parikh, a neonatologist with demonstrated research skills, to become a leader in performing methodologically strong clinical studies of perinatal brain injury in high-risk infants. We propose a comprehensive 5-year career development program involving: 1) Two important clinical studies of brain injury in extremely low birth weight infants: A) A prospective cohort study of quantitative (volumetric) magnetic resonance imaging (MRI) performed at or near term to predict neurosensory impairments at >= 18 months (a study evaluating the properties of quantitative MRI as a diagnostic test, the incremental predictive value over qualitative MRI and routine clinical predictors, and the predictive value of total and regional brain volumes); B) A randomized trial among ventilator-dependent infants (who are conventionally treated with high-dose dexamethasone) to assess whether low-dose hydrocortisone therapy prevents the reduced regional and total cortical volumes common among such infants. These studies will impart research skills in neurodiagnostic tests, neuroprotective strategies, and prognostic assessments for high-risk infants. The findings will be of great interest and pave the way for R01 funding by the end of K23 funding; 2) Intensive mentorship. The primary mentor is a neonatologist and epidemiologist (Jon Tyson, MD, MPH), who is experienced in studies of brain injury, a PI in the NICHD Neonatal Research Network, a PI in the NHLBI Clinical Research Curriculum, Director of the Center for Clinical Research and Evidence Based Medicine, and a dedicated and successful mentor. For the above studies, Dr. Parikh will also have prominent co-mentors in neurology (lan Butler, MD), developmental psychology and quantitative MRI (Robert Lasky, PhD), and neonatology and investigator training (Kathleen Kennedy, MD, MPH, Director, Master's Degree Program in Clinical Research). Dr. Tyson's Center and the Pediatrics Department will support these studies; 3) Master's Degree in Clinical Research (matriculated by Dr. Parikh in Sept. 2003). Courses (36 credit hrs) include Research Ethics, Advanced Biostatistics, and Advanced Epidemiology. His thesis will be a major publication from the above research. Institutional strengths include one of the largest populations of high-risk infants in the US, a strong perinatal research program (1 of only 8 centers in both the NICHD Maternal-Fetal and Neonatal Networks), a neonatal ICU supportive of clinical research (with the largest number of infants randomized in Network trials last year), and a well functioning follow up program. The proposed program will provide Dr. Parikh the research experience, dedicated mentorship, and necessary coursework to become a leader in clinical research addressing perinatal brain injury.
描述(由申请人提供):本提案旨在培养 Nehal Parikh 博士(一位具有出色研究技能的新生儿学家),使其成为对高危婴儿围产期脑损伤进行方法学上强有力的临床研究的领导者。我们提出了一项全面的 5 年职业发展计划,包括: 1) 两项关于极低出生体重婴儿脑损伤的重要临床研究: A) 一项在足月或近期进行的定量(体积)磁共振成像 (MRI) 前瞻性队列研究,用于预测 >= 18 个月时的神经感觉障碍(一项评估定量 MRI 作为诊断测试的特性、相对于定性 MRI 的增量预测值和 常规临床预测因素,以及总脑容量和局部脑容量的预测值); B) 在依赖呼吸机的婴儿(通常接受高剂量地塞米松治疗)中进行的一项随机试验,以评估低剂量氢化可的松治疗是否可以防止此类婴儿中常见的局部和总皮质体积减少。这些研究将传授神经诊断测试、神经保护策略和高危婴儿预后评估方面的研究技能。研究结果将引起极大兴趣,并为 K23 资助结束时的 R01 资助铺平道路; 2)强化辅导。 主要导师是新生儿学家和流行病学家(Jon Tyson,医学博士、公共卫生硕士),他在脑损伤研究方面经验丰富,是 NICHD 新生儿研究网络的 PI、NHLBI 临床研究课程的 PI、临床研究和循证医学中心主任,是一位敬业而成功的导师。对于上述研究,Parikh 博士还将拥有神经病学(lan Butler,医学博士)、发展心理学和定量 MRI(Robert Lasky,博士)以及新生儿学和研究者培训(Kathleen Kennedy,医学博士、公共卫生硕士、临床研究硕士学位项目主任)方面的杰出共同导师。泰森博士中心和儿科将支持这些研究; 3) 临床研究硕士学位(Parikh博士于2003年9月入学)。课程(36 学分)包括研究伦理学、高级生物统计学和高级流行病学。他的论文将成为上述研究的主要出版物。机构优势包括美国最大的高危婴儿群体之一、强大的围产期研究计划(NICHD 母胎和新生儿网络中仅有的 8 个中心之一)、支持临床研究的新生儿 ICU(去年在网络试验中随机分配的婴儿数量最多)以及运作良好的随访计划。拟议的项目将为 Parikh 博士提供研究经验、专门的指导和必要的课程,以成为解决围产期脑损伤的临床研究的领导者。

项目成果

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NEHAL A. PARIKH其他文献

NEHAL A. PARIKH的其他文献

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{{ truncateString('NEHAL A. PARIKH', 18)}}的其他基金

Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI Biomarkers
使用先进 MRI 生物标志物早期预测早产儿脑瘫
  • 批准号:
    9193856
  • 财政年份:
    2016
  • 资助金额:
    $ 16.43万
  • 项目类别:
A New Model to Identify Preterm Neonates at High-Risk for Cognitive Impairments and School Readiness
识别认知障碍和入学准备高风险早产儿的新模型
  • 批准号:
    10442095
  • 财政年份:
    2016
  • 资助金额:
    $ 16.43万
  • 项目类别:
Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI Biomarkers
使用先进 MRI 生物标志物早期预测早产儿脑瘫
  • 批准号:
    9925842
  • 财政年份:
    2016
  • 资助金额:
    $ 16.43万
  • 项目类别:
A New Model to Identify Preterm Neonates at High-Risk for Cognitive Impairments and School Readiness
识别认知障碍和入学准备高风险早产儿的新模型
  • 批准号:
    10620726
  • 财政年份:
    2016
  • 资助金额:
    $ 16.43万
  • 项目类别:
Early Prediction of Cerebral Palsy in Premature Infants using Advanced MRI Biomarkers
使用先进 MRI 生物标志物早期预测早产儿脑瘫
  • 批准号:
    9355482
  • 财政年份:
    2016
  • 资助金额:
    $ 16.43万
  • 项目类别:
Neurological Diseases Research in High Risk Newborns
高危新生儿的神经系统疾病研究
  • 批准号:
    7339682
  • 财政年份:
    2005
  • 资助金额:
    $ 16.43万
  • 项目类别:
Neurological Diseases Research in High Risk Newborns
高危新生儿的神经系统疾病研究
  • 批准号:
    7173351
  • 财政年份:
    2005
  • 资助金额:
    $ 16.43万
  • 项目类别:
Nurological Diseases Research in High Risk Newborns
高危新生儿的神经系统疾病研究
  • 批准号:
    7007695
  • 财政年份:
    2005
  • 资助金额:
    $ 16.43万
  • 项目类别:
Neurological Diseases Research in High Risk Newborns
高危新生儿的神经系统疾病研究
  • 批准号:
    7548114
  • 财政年份:
    2005
  • 资助金额:
    $ 16.43万
  • 项目类别:
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