Functional Language Organization in Childhood Stroke

描述（由申请人提供）：该职业发展奖提案是 旨在让候选人培养成为一名 神经认知发展领域的独立研究者 使用功能性神经影像技术的疾病。该提案的重点是 儿童中风后语言的发展。其具体目标 目的是：（1）发展功能成像任务设计方面的专业知识和 实施以及功能数据的统计分析；和（2） 设计神经系统疾病对认知影响的实证研究 发展。候选人与导师提出为期五年的培训计划 来自儿科研究部门。她的主要导师是一位职能型导师 神经影像研究员，其工作重点是功能磁共振成像在儿童中的应用。 其他导师代表生物统计学、神经学、 心理学、放射学等与研究直接相关的学科 职业发展计划。该计划描述了旨在加强 有效设计和实施功能磁共振成像技术所需的知识 这将为儿科提供有用的临床和科学信息 患者人群。这些活动将包括课程作业、独立 研究和特定的培训轮换。负责任行为的培训 儿科研究和准备拨款的丰富经验 独立研究支持的建议也包含在计划中 程序。该提案研究涉及早期和早期影响的研究 后来认知领域的神经系统发育受到破坏 语言。具体目标包括：（1）映射语言激活模式和 确定早期（围产期）中风儿童的语言偏侧化 与晚期患有左大脑中动脉（MCA）的儿童相比 （发生在 5 至 18 岁同龄之间）左侧 MCA 中风并进行比较 这些模式与同龄和性别的正常儿童的模式相同。 (2) 检查语言功能重组的模式以确定 这种重组是否反映了单向化的转变或内部的转变 半球语言的重新分配。 (3) 追踪语言的变化 随着时间的推移发生的激活模式和语言偏侧化 患有晚期左侧 MCA 中风的儿童。 研究结果将有助于 了解大脑可塑性、语言发展和评估 治疗语言障碍。

DESCRIPTION (provided by applicant): This Career Development Award proposal is designed to allow the candidate to develop the skills necessary to become an independent investigator in the area of neurocognitive development and disorders using functional neuroimaging techniques. The proposal focuses on the development of language after childhood stroke. Its specific objectives are to: (1) develop expertise in functional imaging task design and implementation as well as the statistical analysis of functional data; and (2) design empirical studies of the effects of neurologic disease on cognitive development. The candidate proposes a five- year training program with mentors from a pediatric research department. Her primary mentor is a functional neuroimaging researcher whose work has focused on the use of fMRI in children. Other mentors represent the disciplines of biostatistics, neurology, psychology, and radiology, which are directly relevant to the research and career development plan. The plan describes activities focused on enhancing the knowledge required to effectively design and implement fMRI techniques that will provide useful clinical and scientific information in pediatric patient populations. These activities will include coursework, independent study, and specific training rotations. Training in the responsible conduct of pediatric research and maundered experiences in the preparation of grant proposals for independent research support are also included in the planned program. The proposal research involves the study of the effects of early and later disruption of neurologic development on the cognitive domain of language. Specific aims include: (1) Map language activation patterns and determine language lateralization of children with early (perinatal) stroke of the left middle cerebral artery (MCA) compared to those of children with late (occurring between 5 and 18 years of same age) left MCA stroke and compare these patterns to those of normal children of the same age and gender. (2) Examine the pattern of functional reorganization of language to determine whether such reorganization reflects a shift of lateralization or an intra- hemisphere redistribution of language. (3) Track the changes in language activation patterns and language lateralization that occur over time in children with late left MCA stroke. The findings will contribute to the understanding of brain plasticity, language development, and assessment and treatment of language disorders.