Functional Language Organization in Childhood Stroke

儿童中风的功能性语言组织

基本信息

  • 批准号:
    6889499
  • 负责人:
  • 金额:
    $ 14.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-04-15 至 2007-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This Career Development Award proposal is designed to allow the candidate to develop the skills necessary to become an independent investigator in the area of neurocognitive development and disorders using functional neuroimaging techniques. The proposal focuses on the development of language after childhood stroke. Its specific objectives are to: (1) develop expertise in functional imaging task design and implementation as well as the statistical analysis of functional data; and (2) design empirical studies of the effects of neurologic disease on cognitive development. The candidate proposes a five- year training program with mentors from a pediatric research department. Her primary mentor is a functional neuroimaging researcher whose work has focused on the use of fMRI in children. Other mentors represent the disciplines of biostatistics, neurology, psychology, and radiology, which are directly relevant to the research and career development plan. The plan describes activities focused on enhancing the knowledge required to effectively design and implement fMRI techniques that will provide useful clinical and scientific information in pediatric patient populations. These activities will include coursework, independent study, and specific training rotations. Training in the responsible conduct of pediatric research and maundered experiences in the preparation of grant proposals for independent research support are also included in the planned program. The proposal research involves the study of the effects of early and later disruption of neurologic development on the cognitive domain of language. Specific aims include: (1) Map language activation patterns and determine language lateralization of children with early (perinatal) stroke of the left middle cerebral artery (MCA) compared to those of children with late (occurring between 5 and 18 years of same age) left MCA stroke and compare these patterns to those of normal children of the same age and gender. (2) Examine the pattern of functional reorganization of language to determine whether such reorganization reflects a shift of lateralization or an intra- hemisphere redistribution of language. (3) Track the changes in language activation patterns and language lateralization that occur over time in children with late left MCA stroke. The findings will contribute to the understanding of brain plasticity, language development, and assessment and treatment of language disorders.
描述(由申请人提供):此职业发展奖提案是 旨在让候选人发展成为一名 神经认知发展领域的独立研究者, 使用功能性神经成像技术。提案重点是 儿童中风后语言的发展。其具体目标 是:(1)发展功能成像任务设计的专业知识, 实施以及功能数据的统计分析;以及(2) 设计神经系统疾病对认知功能影响的实证研究 发展候选人提出了一个五年的培训计划, 一个儿科研究部门她的主要导师是一个功能 神经成像研究员,其工作重点是在儿童中使用功能磁共振成像。 其他导师代表生物统计学,神经学, 心理学和放射学,这是直接相关的研究, 职业发展计划。该计划描述了侧重于加强 有效设计和实施fMRI技术所需的知识 这将为儿科提供有用的临床和科学信息, 患者人群。这些活动将包括课程,独立 学习和具体的训练轮换。负责任行为的培训 儿科研究和准备拨款的经验 计划中还包括独立研究支持的建议, 程序.这项研究涉及研究早期和 后来在认知领域的神经发育中断, 语言具体目标包括:(1)地图语言激活模式, 确定早期(围产期)中风儿童的语言偏侧化, 左大脑中动脉(MCA)相比, (发生在5至18岁之间)左侧MCA卒中,并比较 这些模式与同龄和性别的正常儿童的模式相似。(二) 检查语言的功能重组模式,以确定 这种重组是否反映了侧化的转变还是内部的转变 语言的半球再分配。(3)跟踪语言的变化 随着时间的推移, 晚期左侧MCA卒中的儿童。 研究结果将有助于 了解大脑可塑性,语言发展和评估, 治疗语言障碍。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Anna W. Byars其他文献

Validation of the self-report quantified Tuberous Sclerosis Complex-Associated Neuropsyciatric Disorders Checklist (TAND-SQ)
  • DOI:
    10.1186/s13023-025-03642-2
  • 发表时间:
    2025-06-13
  • 期刊:
  • 影响因子:
    3.500
  • 作者:
    Nola Chambers;Tosca-Marie Heunis;Sugnet Gardner-Lubbe;Jamie K. Capal;Stacey Bissell;Anna W. Byars;Sebastián Cukier;Peter E. Davis;Jennifer Flinn;Tanjala T. Gipson;J. Chris Kingswood;Aubrey J. Kumm;Eva Schoeters;Catherine Smith;Shoba Srivastava;Megumi Takei;Stephanie Vanclooster;Agnies M. van Eeghen;Robert Waltereit;Darcy A. Krueger;Mustafa Sahin;Liesbeth De Waele;Anna C. Jansen;Petrus J. de Vries
  • 通讯作者:
    Petrus J. de Vries

Anna W. Byars的其他文献

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{{ truncateString('Anna W. Byars', 18)}}的其他基金

Functional Language Organization in Childhood Stroke
儿童中风的功能性语言组织
  • 批准号:
    6624318
  • 财政年份:
    2002
  • 资助金额:
    $ 14.95万
  • 项目类别:
Functional Language Organization in Childhood Stroke
儿童中风的功能性语言组织
  • 批准号:
    6473679
  • 财政年份:
    2002
  • 资助金额:
    $ 14.95万
  • 项目类别:
Functional Language Organization in Childhood Stroke
儿童中风的功能性语言组织
  • 批准号:
    7035364
  • 财政年份:
    2002
  • 资助金额:
    $ 14.95万
  • 项目类别:
Functional Language Organization in Childhood Stroke
儿童中风的功能性语言组织
  • 批准号:
    6712852
  • 财政年份:
    2002
  • 资助金额:
    $ 14.95万
  • 项目类别:
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