Epidemiology of Traumatic Brain Injury

描述（由申请人提供）：一个有指导的以患者为导向的研究生涯 发展奖（K23）。本提案的总体目标是 在研究方法上给予候选人严格的培训，这样， 建议项目能够顺利完成，并独立研究 职业生涯启动。拟议项目的复杂性和范围，以及 作为申请人的职业目标，有必要获得复杂的 研究技能。申请人的近期职业目标是更好地 了解临床研究的原则和方法，并应用它们 试图建立一个创伤性脑损伤（TBI）监测系统。的 申请人的长期职业目标是建立一种TBI方法 监视，可作为一个模式，门罗县，纽约州和国家 并更好地定义了流行病学和轻微TBI的结果。5年，高 提出了结构化和有指导的培训计划。在头两年， 正式培训，导致在临床公共卫生硕士学位 将在罗切斯特大学医学中心（URMC）进行研究， 进行。涉及的领域包括研究理论、方法和伦理， 特别强调伤害监测方法。导师将 在这些技能的实际应用中提供指导和指导， 而拟议中的研究项目已经开始。在接下来的三年里， 研究项目将更仔细地制定和实施，数据 收集和提出的假设进行了测试，所有这些都是在 导师这项名为“脑外伤流行病学"的研究计划， 是一项前瞻性观察性队列研究， 到URMC的急诊科（艾德），满足CDC定义的病例 TBI的定义详细的人口统计学和流行病学数据，包括 受伤的机制和地理位置，将在退出前收集 结果数据将通过结构化电话访谈收集， 符合轻度TBI研究定义的TBI患者亚组。这 将允许测试与流行病学相关的几个假设， 轻微TBI的结果，确定最完整的方法， 艾德环境中的监测收集，以及 轻微TBI对纽约州门罗县的经济影响。

DESCRIPTION (provided by applicant): A Mentored PatientOriented Research Career Development Award (K23) is proposed. The overall goal of this proposal is to give the candidate a rigorous training in research methods, such that the proposed project can be successfully completed and an independent research career be launched. The complexity and scope of the proposed project, as well as the applicant's career goals, necessitate the acquisition of sophisticated research skills. The applicant's immediate career objectives are to better understand the principles and methods of clinical research, and to apply them in an effort to set up a traumatic brain injury (TBI) surveillance system. The applicant's longterm career goals are to have established a method of TBI surveillance that can be used as a model for Monroe County, NY and the nation and better defined the epidemiology and outcome from minor TBI. A 5year, highly structured and mentored training plan is proposed. During the first 2 years, formal training leading to a degree in Masters of Public Health in Clinical Investigation at the University of Rochester Medical Center (URMC) will be undertaken. Areas to be covered include research theory, methods and ethics, with special emphasis on injury surveillance methodology. The mentor will provide instruction and guidance in the practical application of these skills, while the proposed research project is begun. During the following 3 years, the research project will be more carefully developed and implemented, data collected and proposed hypotheses tested, all under the careful guidance of the mentor. The proposed research plan, entitled "Epidemiology of Traumatic Brain Injury," is a prospective observational cohort study of all patients presenting to the Emergency Department (ED) of the URMC meeting the CDC-defined case definition of TBI. Detailed demographic and epidemiologic data, including mechanism and geographic location of injury, will be collected before exiting the ED. Outcome data will be collected via structured telephone interview on the subgroup of TBI patients who meet the study definition of minor TBI. This will permit the testing of several hypotheses related to the epidemiology and outcome from minor TBI, the determination of the most complete method of surveillance datacollection in an ED setting, and the estimation of the economic impact of minor TBI on Monroe County, NY.