Epidemiology of Traumatic Brain Injury

描述(由申请人提供)：有指导的、以患者为导向的研究生涯 提出了发展奖(K23)。这项建议的总体目标是在研究方法方面给予应聘者严格的培训，以便 拟建项目可顺利完成并独立研究 职业生涯即将启动。拟议项目的复杂性和范围 作为应聘者的职业目标，有必要获得成熟的 研究技能。申请人的直接职业目标是更好地 了解临床研究的原理和方法，并加以应用 努力建立创伤性脑损伤(TBI)监测系统。这个 应聘者的长期职业目标是建立一种基于任务的教学方法 监控可以作为纽约州门罗县和全国的典范 并更好地定义了轻微脑外伤的流行病学和预后。一个5年，高度 提出了结构化和指导性的培训计划。在头两年， 通过正规培训获得临床公共卫生硕士学位 罗切斯特大学医学中心(URMC)的调查将是 承担了。将涵盖的领域包括研究理论、方法和伦理， 特别强调伤害监测方法。导师将会 就这些技能的实际应用提供指导和指导， 在拟议的研究项目开始的同时。在接下来的三年里， 研究项目将更仔细地制定和实施，数据 收集和提出的假设进行了测试，所有这些都是在 门托。拟议的研究计划，题为《创伤性脑的流行病学》 是一项对所有患者进行的前瞻性观察队列研究 至市建管委会急症室处理疾控中心所界定的个案 TBI的定义。详细的人口和流行病学数据，包括 受伤的机制和地理位置，将在离开前收集 艾德。结果数据将通过结构化电话采访收集，时间为 符合轻度脑外伤研究定义的脑外伤患者亚组。这 将允许测试几个与流行病学相关的假设和 轻微颅脑损伤的结局，确定最完整的治疗方法 ED环境中的监测数据收集，以及对 轻微TBI对纽约州门罗县的经济影响。

DESCRIPTION (provided by applicant): A Mentored PatientOriented Research Career Development Award (K23) is proposed. The overall goal of this proposal is to give the candidate a rigorous training in research methods, such that the proposed project can be successfully completed and an independent research career be launched. The complexity and scope of the proposed project, as well as the applicant's career goals, necessitate the acquisition of sophisticated research skills. The applicant's immediate career objectives are to better understand the principles and methods of clinical research, and to apply them in an effort to set up a traumatic brain injury (TBI) surveillance system. The applicant's longterm career goals are to have established a method of TBI surveillance that can be used as a model for Monroe County, NY and the nation and better defined the epidemiology and outcome from minor TBI. A 5year, highly structured and mentored training plan is proposed. During the first 2 years, formal training leading to a degree in Masters of Public Health in Clinical Investigation at the University of Rochester Medical Center (URMC) will be undertaken. Areas to be covered include research theory, methods and ethics, with special emphasis on injury surveillance methodology. The mentor will provide instruction and guidance in the practical application of these skills, while the proposed research project is begun. During the following 3 years, the research project will be more carefully developed and implemented, data collected and proposed hypotheses tested, all under the careful guidance of the mentor. The proposed research plan, entitled "Epidemiology of Traumatic Brain Injury," is a prospective observational cohort study of all patients presenting to the Emergency Department (ED) of the URMC meeting the CDC-defined case definition of TBI. Detailed demographic and epidemiologic data, including mechanism and geographic location of injury, will be collected before exiting the ED. Outcome data will be collected via structured telephone interview on the subgroup of TBI patients who meet the study definition of minor TBI. This will permit the testing of several hypotheses related to the epidemiology and outcome from minor TBI, the determination of the most complete method of surveillance datacollection in an ED setting, and the estimation of the economic impact of minor TBI on Monroe County, NY.