Development of a Telemetric Monitor for IOP

描述(申请人提供)：本提案的目的是开发和实施一种遥测眼压监测系统，该系统可以用来获得长时间连续的、全天候的眼压数据。遥测24小时眼压表征很重要，原因有两个。首先，它将为研究个体视神经头部对IOP的易感性的实验、计算和理论研究奠定基础。其次，它将为青光眼患者的遥测眼压监测和临床实现真正的24小时眼压控制奠定基础。 具体的目的和目标是：1)开发遥测眼压监测仪；2)开发必要的软件，使遥测24小时眼压数据可视化和定性化；3)使用在具体目标1和2中开发的硬件和软件，在6个月内捕获24小时眼压数据并确定其特征。 该方法包括通过将换能器集成到LSD设计的、眼外巩膜固定的硅胶基板中来改进现有的经过验证的设计(DISS T-27-F系列植入物)的电池供电的植入式皮下压力监测器，该基板通过硅胶管连接到前房。与DIS系统相关的硬件和软件将专门针对24小时眼压数据的捕获、可视化和量化进行优化。用于可视化和量化眼睛随着时间的推移暴露到的眼压水平的定制自动化算法将被开发并在软件中实现。该系统准确捕捉眼压昼夜波动模式(幅度、频率和持续时间)的能力以及其准确记录短期眼压波动的能力(如眨眼和揉眼睛的情况)将得到表征。 其目标是为长期(至少12个月)、24小时远程眼压监测提供成熟的交钥匙解决方案。这样的系统将推进青光眼研究，并为眼压在青光眼视神经病变的发生和发展中所起的作用提供有价值的见解。

DESCRIPTION (provided by applicant): The purpose of the present proposal is to develop and implement a telemetric IOP monitoring system that can be used to obtain continuous, round-the-clock IOP data over long periods of time. Telemetric 24-hour IOP characterization is important for two reasons. First, it will lay the foundation for experimental, computational, and theoretical studies to investigate individual optic nerve head susceptibility to IOP. Second, it will lay the foundation for telemetric IOP monitoring of glaucoma patients and the clinical achievement of true, 24-hour intraocular pressure control. The Specific Aims and Objectives are 1) to develop a telemetric IOP monitor; 2) to develop the software necessary to visualize and characterize telemetric 24-hour IOP data; and 3) to use the hardware and software developed in Specific Aims 1 and 2 to capture and characterize 24-hour IOP data over a 6-month period. The Methodology includes modifying an existing subcutaneous, battery-powered, implantable pressure monitor of proven design (DISS T-27-F series implant) by integrating the transducer into an LSD-designed, extraocular, sclera-fixated, silicone baseplate that is connected to the anterior chamber via a silicone tube. Hardware and software associated with the DISS system will be specifically optimized for the capture, visualization, and quantification of 24-hour IOP data. Custom, automated algorithms for visualizing and quantifying the IOP levels to which the eye is exposed over time will be developed and implemented in software. The system's ability to accurately capture the pattern of diurnal IOP fluctuation (magnitude, frequency, and duration) will be characterized, as will its ability to accurately record short-term IOP fluctuations as in the case of blink and eye rub. The goal is to provide a mature, turnkey solution for long-term (minimum 12 month), 24-hour, telemetric IOP monitoring. Such a system will advance glaucoma research and yield valuable insight into the role of IOP in the development and progression of glaucomatous optic neuropathy.