Training Grant in Dynamic Aspects of Chemical Biology

描述（由申请人提供）：本申请要求继续支持堪萨斯大学化学、药物化学和分子生物科学系化学生物学动态方面的博士培训计划。 该培训计划旨在教育化学科学博士毕业生，他们将拥有生物信息和技能的工作水平，以及生物科学博士毕业生，他们将掌握化学信息和技能。堪萨斯大学的该计划利用了当地50多年来科学家在化学，生物学和制药科学领域密切有效合作的传统。导师将从参与部门中抽取：化学11.5名教师，分子生物科学6.5名，药物化学6名，药理学和毒理学1名（0.5反映了药物化学和化学联合任命的教师）。请求为7名受训人员提供支助，比上一次申请增加了1名。受训人员完成一个程序，其特点是集中在博士教育和研究领域的既定优势;课程的课程，扩大了信息和技能的受训人员到超越部门界限的领域;研究轮换，让受训人员在该计划的所有领域的个人研究经验;和参与组织和演示在特别研讨会和年度研讨会。学员的博士研究项目分为三个领域：（1）生物相关分子的合成;（2）生物物理结构分析;（3）酶机制和生物分子动力学。培训补助金课程从生物信息学和/或分子建模的核心课程开始，沿着一门课程，科学完整性问题。然后，每个化学和药物化学的学生必须采取至少一个选修课程的分子生物科学，反之亦然。此外，受训人员符合其所在部门的所有博士要求。所有受训人员进行两次研究轮换。学员管理并参加年度培训补助金研讨会，以及邀请化学生物学研讨会的演讲者。

DESCRIPTION (provided by applicant): This application requests continued support for the doctoral training program in Dynamic Aspects of Chemical Biology in the Departments of Chemistry, Medicinal Chemistry, and Molecular Biosciences at the University of Kansas. This training program aims to educate doctoral graduates in the chemical sciences who will have a working level of biological information and skills, and doctoral graduates in the biological sciences who will have a command of chemical information and skills. The program at the University of Kansas takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Mentors will be drawn from the participating departments: 11.5 faculty members from Chemistry, 6.5 from Molecular Biosciences, 6 from Medicinal Chemistry, and 1 from Pharmacology and Toxicology (the 0.5 reflects a faculty member with joint appointments in Medicinal Chemistry and Chemistry). Support is requested for seven trainees, an increase of one from the previous submission. Trainees complete a program that features focused doctoral education and research in an area of established strength; a curriculum of courses that broadens the information and skills of trainees into areas beyond departmental boundaries; research rotations that give trainees personal research experience in all areas of the program; and participation in both organization of and presentation at special seminars and an annual symposium. The doctoral research projects of trainees fall into one of three areas: (1) synthesis of molecules of biological relevance; (2) biophysical structure analysis; (3) enzyme mechanisms and biomolecular dynamics. The training-grant curriculum begins with core courses in bioinformatics and/or molecular modeling, along with a course, Issues in Scientific Integrity. Then each chemistry and medicinal chemistry student is required to take at least one elective course in molecular biosciences and vice versa. In addition, trainees meet all doctoral requirements of their home departments. All trainees carry out two research rotations. Trainees manage and participate in the Annual Training Grant Symposium as well as in inviting speakers for a Chemical Biology seminar.