Kinetics and Mechanism of Pd(II) X-OH Anion Metathesis in the Suzuki-Miyaura Reaction

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Palladium-catalysed cross-coupling is incredibly important in synthetic chemistry. The Suzuki-Miyaura reaction in particularis one of the most widely used C-C bond forming processes and is routinely employed in pharmaceutical and agrochemicalsynthesis on small (mmol) to large (tonne) scale. Side reactions such as Ar-X reduction and protodeboronation are oftenencountered in the Suzuki-Miyaura reaction. These unwanted reactions can consume valuable starting materials, impedeproductive catalyst turnover, and complicate purification. This project will develop an understanding of a key mechanisticevent in the Suzuki-Miyaura reaction and use this information to try to eliminate these problems and improve the synthesisof pharmaceutically- and agrochemical-relevant molecules.This project aims to establish the mechanism and kinetics of the X-OH anion metathesis event of the Suzuki-Miyaura reaction and use this information to develop better catalysis. The student will receive a diverse training in kinetics,mechanism, organic chemistry, organometallic chemistry, spectroscopy, and synthesis, as well as becoming well-versed inindustrially-relevant catalysis.