Kinetics and Mechanism of Pd(II) X-OH Anion Metathesis in the Suzuki-Miyaura Reaction

Suzuki-Miyaura 反应中 Pd(II) X-OH 阴离子复分解的动力学和机理

• 批准号: 2493504
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2493504
• 关键词: Kinetics; Mechanism; Pd; II; OH

Palladium-catalysed cross-coupling is incredibly important in synthetic chemistry. The Suzuki-Miyaura reaction in particularis one of the most widely used C-C bond forming processes and is routinely employed in pharmaceutical and agrochemicalsynthesis on small (mmol) to large (tonne) scale. Side reactions such as Ar-X reduction and protodeboronation are oftenencountered in the Suzuki-Miyaura reaction. These unwanted reactions can consume valuable starting materials, impedeproductive catalyst turnover, and complicate purification. This project will develop an understanding of a key mechanisticevent in the Suzuki-Miyaura reaction and use this information to try to eliminate these problems and improve the synthesisof pharmaceutically- and agrochemical-relevant molecules.This project aims to establish the mechanism and kinetics of the X-OH anion metathesis event of the Suzuki-Miyaura reaction and use this information to develop better catalysis. The student will receive a diverse training in kinetics,mechanism, organic chemistry, organometallic chemistry, spectroscopy, and synthesis, as well as becoming well-versed inindustrially-relevant catalysis.

钯催化的交叉偶联在合成化学中非常重要。特别是Suzuki-Miyaura反应是最广泛使用的C-C键形成过程之一，通常用于小（mmol）到大（吨）规模的制药和农用化学品合成。副反应如Ar-X还原和原波化反应在Suzuki-Miyaura反应中经常遇到。这些不需要的反应会消耗有价值的起始材料，阻碍生产催化剂的周转，并使净化变得复杂。该项目将对Suzuki-Miyaura反应中的一个关键机械事件进行理解，并利用这些信息试图消除这些问题，并改进制药和农用化学品相关分子的合成。本项目旨在建立Suzuki-Miyaura反应中X-OH阴离子复分解事件的机理和动力学，并利用这些信息开发更好的催化剂。该学生将接受动力学、机理、有机化学、有机金属化学、光谱学和合成等方面的培训，并精通工业相关的催化。