Attentional Dysfunction in Children with Phenylketonuria

苯丙酮尿症儿童注意力障碍

• 批准号: 6901946
• 负责人: GEORGIANNE L ARNOLD
• 金额: $ 12.68万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-07 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6901946
• 关键词: attention deficit disorder; behavioral /social science research tag; child behavior; clinical research; cognition; functional ability; human subject; intelligence tests; middle childhood (6-11); neuropsychological tests; neuropsychology; patient oriented research; phenylalanine; phenylketonurias; siblings

DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award will prepare the applicant for a career in patient-oriented clinical research in the field of inborn errors of metabolism. Increased recognition and survival in children with metabolic disorders have created a great need for metabolic clinicians trained in clinical research. In particular the cognitive and behavioral profiles of children these children remain largely unexplored and worldwide few clinicians have the requisite skills and training to conduct these studies. The candidate plans to: 1) acquire didactic instruction in clinical research skills as well as familiarity with the fundamentals of cognition and neuropsychology, and 2) complete a mentored clinical research study on attentional dysfunction among children with phenylketonuria (PKU). The candidate's long-term goal is to develop a series of funded clinical investigations to improve biological and psychological outcomes in children with phenylketonuria and other inborn errors of metabolism. The University of Rochester School of Medicine and Dentistry provides a rich environment for conducting clinical research, and recently developed a formal curriculum for training candidates in clinical research. At the completion of the five-year period, the applicant will have the skills necessary to conduct funded clinical research, and the applicant's work will have the potential to contribute significantly to the body of patient-oriented clinical research in the field of inborn errors of metabolism.

描述（由申请人提供）： 这个指导以患者为导向的研究职业发展奖将准备申请人在先天性代谢缺陷领域的以患者为导向的临床研究的职业生涯。随着对代谢紊乱儿童的认识和生存率的提高，对经过临床研究培训的代谢临床医生产生了巨大的需求。特别是儿童的认知和行为特征，这些儿童在很大程度上仍未被探索，世界范围内很少有临床医生具有进行这些研究所需的技能和培训。候选人计划：1）获得临床研究技能的教学指导，以及熟悉认知和神经心理学的基础知识，2）完成对苯丙酮尿症（PKU）儿童注意力障碍的指导临床研究。候选人的长期目标是开发一系列资助的临床研究，以改善苯丙酮尿症和其他先天性代谢缺陷儿童的生物和心理结果。罗切斯特大学医学和牙科学院为开展临床研究提供了丰富的环境，最近开发了一个正式的课程，用于培训临床研究的候选人。在五年期结束时，申请人将拥有进行资助的临床研究所需的技能，申请人的工作将有可能为先天性代谢缺陷领域以患者为导向的临床研究做出重大贡献。