Cardiovascular-Oxytocin Links in Social Interaction

社交互动中的心血管-催产素联系

• 批准号: 6920751
• 负责人: TIMOTHY W SMITH
• 金额: $ 40.37万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-15 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6920751
• 关键词: African American; age difference; angers; behavioral /social science research tag; behavioral medicine; cardiovascular function; caucasian American; clinical research; conflict; cortisol; dyadic interaction; gender difference; human middle age (35-64); human subject; oxytocin; personality; psychological stressor; racial /ethnic difference; social adjustment; spouses; stress; young adult human (21-34)

DESCRIPTION (provided by applicant): Social isolation and low social support are associated with increased risk of coronary heart disease and death, presumably through the mechanism of cardiovascular and neuroendocrine reactivity to potential stressors. There is mounting evidence of an association between social support and psychophysiological responses, but the experimental studies have not examined support in the context of actual social network relationships, nor have they examined the likely moderating effects of trait hostility and relationship quality. Further, the role of stress reducing neuroendocrine bases of affiliation and attachment have not been examined in this context. The studies proposed will address these issues in married couples. Couples will complete one of three dyadic interaction tasks (supportive, neutral, or conflictual), followed by individual participation in a stressful speaking task. Concurrent effects of supportive and conflictual social interaction on blood pressure, catecholamine, cortisol and oxytocin responses will be examined, as will "carry over" effects of social interaction on changes in these same variables during the subsequent stressful task. We predict that supportive interactions between spouses will be associated with decreased concurrent and subsequent cardiovascular, catecholamine, and cortisol responses, and that conflcitual interactions will heighten these responses. Further, we will examine changes in oxytocin as a possible mediator of these effects. We also expect that individual differences in trait hostility and prior relationship quality will moderate the concurrent and carryover effects of social interaction on these physiological responses. Study one will test the moderation of these effects across the age range of 18 to 50 years. Study two will compare these effects in Caucasians and African Americans. Explication of the psychobiology of social support and related psychosocial risk factors in personal relationships could guide the refinement of risk reducing, preventive interventions.

描述（由申请人提供）：通过心血管和神经内分泌对潜在压力源的反应性的机制，社会隔离和低社会支持与冠心病和死亡的风险增加有关。有越来越多的证据表明，社会支持与心理生理学反应之间存在关联，但是实验研究并未在实际的社交网络关系中检查支持，也没有研究过特质敌意和关系质量的可能调节作用。此外，在这种情况下，尚未检查压力减少隶属关系和依恋的神经内分泌基础的作用。提出的研究将在已婚夫妇中解决这些问题。夫妻将完成三个二元互动任务之一（支持性，中立或冲突），然后是个人参与压力大的说话任务。支持性和冲突的社会互动对血压，儿茶酚胺，皮质醇和催产素反应的同时影响，在随后的压力任务中，社会互动对这些相同变量的变化的“延续”也将“延续”社会互动的影响。我们预测，配偶之间的支持性相互作用将与并发和随后的心血管，儿茶酚胺和皮质醇反应减少有关，并且混合性相互作用将增强这些反应。此外，我们将研究催产素的变化，作为这些作用的可能介体。我们还期望，特质敌意和先前关系质量的个体差异将减轻社会互动对这些生理反应的同时和结转影响。研究将在18至50岁的年龄范围内测试这些影响的适度。研究两个将比较这些影响在高加索人和非洲裔美国人中。在人际关系中对社会支持和相关心理心理风险因素的心理生物学的阐述可以指导降低风险的改进，预防性干预措施。

项目成果

Effects of couple interactions and relationship quality on plasma oxytocin and cardiovascular reactivity: empirical findings and methodological considerations.

• DOI: 10.1016/j.ijpsycho.2012.04.006
• 发表时间: 2013-06
• 期刊: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
• 影响因子: 3
• 作者: Smith, Timothy W.;Uchino, Bert N.;MacKenzie, Justin;Hicks, Angela M.;Campo, Rebecca A.;Reblin, Maija;Grewen, Karen M.;Amico, Janet A.;Light, Kathleen C.
• 通讯作者: Light, Kathleen C.

Knowing your partner is not enough: spousal importance moderates the link between attitude familiarity and ambulatory blood pressure.

了解您的伴侣还不够：配偶重要性调节态度熟悉度与动态血压之间的联系。

• DOI: 10.1007/s10865-012-9437-x
• 发表时间: 2013
• 期刊: Journal of behavioral medicine
• 影响因子: 3.1
• 作者: Uchino,BertN;Sanbonmatsu,DavidM;Birmingham,Wendy
• 通讯作者: Birmingham,Wendy

Attitude similarity and familiarity and their links to mental health: An examination of potential interpersonal mediators.

• DOI: 10.1080/00224545.2016.1176551
• 发表时间: 2017
• 期刊: The Journal of social psychology
• 作者: Moore SM;Uchino BN;Baucom BR;Behrends AA;Sanbonmatsu D
• 通讯作者: Sanbonmatsu D

Specific dimensions of perceived support and ambulatory blood pressure: which support functions appear most beneficial and for whom?

• DOI: 10.1016/j.ijpsycho.2012.03.004
• 发表时间: 2013-06
• 期刊: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
• 影响因子: 3
• 作者: Bowen, Kimberly S.;Birmingham, Wendy;Uchino, Bert N.;Carlisle, McKenzie;Smith, Timothy W.;Light, Kathleen C.
• 通讯作者: Light, Kathleen C.

The quality of spouses' social networks contributes to each other's cardiovascular risk.

配偶社交网络的质量会影响彼此的心血管风险。

• DOI: 10.1371/journal.pone.0071881
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Uchino,BertN;Smith,TimothyW;Carlisle,McKenzie;Birmingham,WendyC;Light,KathleenC
• 通讯作者: Light,KathleenC