REGULATION OF CYP1A1 IN HUMAN EPITHELIAL CELLS

人类上皮细胞中 CYP1A1 的调节

• 批准号: 6950448
• 负责人: B LYNN ALLEN-HOFFMANN
• 金额: $ 23.35万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6950448
• 关键词: carbopolycyclic compound; cell adhesion; cell differentiation; cytochrome P450; drug receptors; enzyme induction /repression; epithelium; gene expression; human subject; keratinocyte; laboratory mouse; skin; tissue /cell culture

项目成果

Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen.

缺氧会抑制人类皮肤模型中的基底角质形成细胞增殖，并诱导表皮粘附连接蛋白、水通道蛋白-3 和糖原分布的区域特异性变化。

• DOI: 10.1111/j.1524-475x.2009.00515.x
• 发表时间: 2009
• 期刊: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
• 作者: Straseski,JoelyA;Gibson,AngelaL;Thomas-Virnig,ChristinaL;Allen-Hoffmann,BLynn
• 通讯作者: Allen-Hoffmann,BLynn

TCDD induces dermal accumulation of keratinocyte-derived matrix metalloproteinase-10 in an organotypic model of human skin.

• DOI: 10.1016/j.taap.2014.02.010
• 发表时间: 2014-05-01
• 期刊: TOXICOLOGY AND APPLIED PHARMACOLOGY
• 影响因子: 3.8
• 作者: De Abrew, K. Nadira;Thomas-Virnig, Christina L.;Rasmussen, Cathy A.;Bolterstein, Elyse A.;Schlosser, Sandy J.;Allen-Hoffmann, B. Lynn
• 通讯作者: Allen-Hoffmann, B. Lynn

Chimeric composite skin substitutes for delivery of autologous keratinocytes to promote tissue regeneration.

• DOI: 10.1097/sla.0b013e3181c1ab5f
• 发表时间: 2010-02
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Rasmussen CA;Gibson AL;Schlosser SJ;Schurr MJ;Allen-Hoffmann BL
• 通讯作者: Allen-Hoffmann BL