Motivation and Attention in Marijuana Use and Withdrawal

大麻使用和戒断的动机和注意力

• 批准号: 6881456
• 负责人: ANTHONY LIGUORI
• 金额: $ 21.53万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6881456
• 关键词: attention; behavioral /social science research tag; clinical research; cognition disorders; computer data analysis; drug /alcohol abstinence; drug withdrawal; human subject; intelligence tests; longitudinal human study; marijuana abuse; memory disorders; motivation; neural information processing; neuropsychological tests; performance; psychological tests; questionnaires; short term memory; urinalysis

DESCRIPTION (provided by applicant): Marijuana use impairs memory, attention, and executive functioning. These impairments increase with long-term use. While several studies have reported residual cognitive impairments within days of abstinence from long-term use, the extent to which marijuana-induced cognitive performance deficits extend further into the abstinence period has received little study. These cognitive deficits may be further confounded by residual impairing effects of marijuana on motivation. That is, cognitive performance deficits during abstinence from heavy marijuana use may be due to impairment of processing ability, diminished motivation to perform well, or both. The goal of this research proposal is to fill these two critical knowledge gaps by quantifying marijuana withdrawal effects on memory and attention. We will repeatedly test memory and attention in marijuana-dependent adults with a heavy use history both before and during withdrawal from chronic marijuana use. A group of former light users will serve as a control group. We will also isolate the role of motivational drive in marijuana-related and withdrawal-related impairments. Monetary incentive for accurate performance will be provided to separate groups of marijuana abstinent adults and control subjects. The key dependent variable will be improvement of performance over repeated testing. Testing during abstinence will coincide with the ascent (day 1), peak (day 3), and descent (days 7 and 21) of the typical withdrawal syndrome. By quantifying cognitive impairment, then dissociating processing deficit from effort expended, the proposed studies will further our understanding of the effects of THC on cognitive performance before and after abstinence.

描述（由申请人提供）：滥用会损害记忆力、注意力和执行功能。这些损害随着长期使用而增加。虽然有几项研究报告了长期使用大麻后几天内的残留认知障碍，但大麻引起的认知功能障碍在多大程度上进一步延伸到禁欲期却很少有研究。这些认知缺陷可能会进一步混淆大麻对动机的残余损害作用。也就是说，在大量使用大麻戒断期间的认知表现缺陷可能是由于加工能力受损，表现良好的动机减弱，或两者兼而有之。这项研究提案的目标是通过量化大麻戒断对记忆和注意力的影响来填补这两个关键的知识空白。我们将反复测试大麻依赖成年人的记忆力和注意力，这些成年人在长期使用大麻之前和期间都有大量使用大麻的历史。一组前轻度使用者将作为对照组。我们还将分离动机驱动在大麻相关和戒断相关损伤中的作用。将为不同的大麻戒断成年人和对照组提供准确表现的金钱激励。关键因变量将是重复测试的性能改善。戒断期间的测试将与典型戒断综合征的上升（第1天），高峰（第3天）和下降（第7天和第21天）相一致。通过量化认知障碍，然后将处理缺陷与所花费的努力分离，拟议的研究将进一步了解THC对禁欲前后认知表现的影响。