Mechanisms of Cocaine Induced Long-term Potentiation
可卡因诱导长时程增强的机制
基本信息
- 批准号:6878935
- 负责人:
- 金额:$ 24.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-04-01 至 2006-03-31
- 项目状态:已结题
- 来源:
- 关键词:AMPA receptorsbehavioral habituation /sensitizationbrain electrical activitycell cell interactioncell population studychemical structure functioncocaineimmunocytochemistryintermolecular interactionlaboratory ratlong term potentiationneural plasticityneural transmissionneurogeneticsneuronsneuropharmacologyneuroregulationphosphorylationreceptor couplingreceptor expressionsecond messengerssynapsestegmentumvoltage /patch clampwestern blottings
项目摘要
DESCRIPTION (provided by applicant): The goal of the present proposal is to
understand the cellular and synaptic events through which cocaine induces
long-term plasticity at excitatory synapses in the ventral tegmental area (VTA)
after a single in vivo exposure. The VTA considered to play a central role in
the initiation of drug-related behaviors such as behavioral sensitization, but
the cellular mechanisms that underlie the initiation of such behavioral
phenomena are still obscure. Our preliminary data suggest that a single
injection of cocaine produces a long-term potentiation (LTP) of
AMPA-receptor-mediated post-synaptic currents in the VTA. Furthermore, when
mice were challenged with a second injection of cocaine, they displayed
context-dependent behavioral sensitization. Further, both cocaine-induced LTP
and context-dependent behavioral sensitization are blocked by the NMDA receptor
antagonist MK-801.
Our first goal is to determine whether the expression of cocaine-induced LTP
involves a change in AMPA receptor number, function, or both. Second, we will
perform intra-VTA in vivo injections to understand whether intra-VTA injections
of cocaine are sufficient for cocaine to induce LTP, and to define the
receptors and second messengers involved in producing the cocaine-induced LTP.
Third, we will use an in vitro model to study which receptors in the VTA are
involved in producing the cocaine-mediated long-term potentiation. Fourth, we
will determine whether such cocaine dependent LTP also occurs in tertiary
cells, a group of VTA neurons whose function is still unknown. Our long-term
goal is to understand the complete sequence of cellular and molecular events
through which cocaine produces LTP at AMPA receptors in the VTA and the
subsequent initiation of behavioral sensitization.
描述(由申请人提供):本提案的目标是
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANTONELLO BONCI其他文献
ANTONELLO BONCI的其他文献
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{{ truncateString('ANTONELLO BONCI', 18)}}的其他基金
CRF modulation of NMDA Currents & Behavior in the VTA
NMDA 电流的 CRF 调制
- 批准号:
7039156 - 财政年份:2004
- 资助金额:
$ 24.11万 - 项目类别:
CRF modulation of NMDA Currents & Behavior in the VTA
NMDA 电流的 CRF 调制
- 批准号:
7192576 - 财政年份:2004
- 资助金额:
$ 24.11万 - 项目类别:
CRF Modulation of NMDA Currents and Behavior in the VTA
NMDA 电流的 CRF 调制和 VTA 中的行为
- 批准号:
7736205 - 财政年份:2004
- 资助金额:
$ 24.11万 - 项目类别:
CRF modulation of NMDA Currents & Behavior in the VTA
NMDA 电流的 CRF 调制
- 批准号:
6915478 - 财政年份:2004
- 资助金额:
$ 24.11万 - 项目类别:
CRF modulation of NMDA Currents & Behavior in the VTA
NMDA 电流的 CRF 调制
- 批准号:
6775287 - 财政年份:2004
- 资助金额:
$ 24.11万 - 项目类别:
Mechanisms of Cocaine Induced Long-term Potentiation
可卡因诱导长时程增强的机制
- 批准号:
6463435 - 财政年份:2002
- 资助金额:
$ 24.11万 - 项目类别:
Synaptic plasticity in the VTA after behavioral sensitization & cocaine self-admi
行为敏化后 VTA 的突触可塑性
- 批准号:
7208307 - 财政年份:2002
- 资助金额:
$ 24.11万 - 项目类别:
Synaptic plasticity in the VTA after behavioral sensitization & cocaine self-admi
行为敏化后 VTA 的突触可塑性
- 批准号:
7408122 - 财政年份:2002
- 资助金额:
$ 24.11万 - 项目类别:
Synaptic plasticity in the VTA after behavioral sensitization & cocaine self-admi
行为敏化后 VTA 的突触可塑性
- 批准号:
7536097 - 财政年份:2002
- 资助金额:
$ 24.11万 - 项目类别:
Mechanisms of Cocaine Induced Long-term Potentiation
可卡因诱导长时程增强的机制
- 批准号:
6727616 - 财政年份:2002
- 资助金额:
$ 24.11万 - 项目类别:














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