2006 Muscle: Excitation/Contraction Coupling Gordan Conference

描述（由申请人提供）：本提案是为了支持唯一一个致力于骨骼肌兴奋收缩耦合和改变这一过程的疾病的国际会议。肌肉：兴奋收缩戈登会议将于2006年6月4日至9日在新罕布什尔州新伦敦的科尔比-索耶学院举行，大约有150名与会者。这个会议开始于1970年，从那时起每三年召开一次。2006年，该会议将有31位代表8个不同国家的发言人。由于公开讨论是成功的戈登会议的关键部分，我们留出了相当长的讨论时间，并将有18位讨论主持人。主题包括E-C偶联蛋白的结构和相互作用，E-C偶联的调节和调节，E-C偶联蛋白在肌肉疾病中的作用，以及兴奋转录偶联。2006年会议将讨论肌肉损伤和修复，特别强调细胞内Ca2+浓度变化的作用。从历史上看，兴奋-收缩耦合戈登会议和离子通道戈登会议都是从早期的戈登会议发展而来的，该会议不仅讨论了与肌肉有关的问题，而且还讨论了更广泛的离子通道问题。显然，这两个领域是重叠的，并且可以相互做出很大贡献。因此，组织2006年EC耦合会议的一个重要目标是将研究非肌肉系统（如免疫系统和神经系统）中离子通道和钙信号的主要研究人员纳入会议。最近的研究表明，肌肉具有类似于不可兴奋细胞的钙再填充途径，因此这一点变得尤为重要。

DESCRIPTION (provided by applicant): This proposal is for support of the only international meeting dedicated to skeletal muscle excitation contraction coupling and the diseases that alter this process. The Muscle: Excitation Contraction Gordon conference will meet June 4-9, 2006 at Colby-Sawyer College in New London, New Hampshire and will have approximately 150 participants. This conference began in 1970 and has met every 3 years since that time. In 2006, this conference will have 31 speakers representing 8 different counties. Since open discussion is a crucial part of a successful Gordon conference, we have allowed considerable time for discussion and will have 18 discussion leaders. Topics include structure and interactions of E-C coupling proteins, modulation and regulation of E-C coupling, the role of E-C coupling proteins in muscle disease, and excitation transcription coupling. New to the 2006 conference will be a discussion of muscle damage and repair with a particular emphasis on the role in alterations in intracellular Ca2+ concentrations. Historically, both the Excitation-Contraction Coupling Gordon Conference and the Ion Channel Gordon Conference emerged from an earlier Gordon Conference which addressed issues relating not only to muscle in particular but also to ion channels more generally. Clearly, the two fields overlap and have much to contribute to one another. Thus, an important goal for organizing the 2006 EC coupling conference was to incorporate leading investigators working on ion channels and calcium signaling in non-muscle systems such as the immune and nervous systems. This has become particularly relevant since recent work has demonstrated the muscle possesses calcium refilling pathways similar to those of non-excitable cells.