2005 Antimicrobial Peptides Gordon Conference

描述（由申请人提供）：第五届半年度戈登抗菌肽（AMP）研究会议将于2005年3月6日至11日在加州文图拉举行。抗药性微生物的出现强调了研究内源性物质的必要性。抗菌肽是内源性的，基因编码的抗生素，发现在每一个物种的调查，包括无脊椎动物，植物，脊椎动物和哺乳动物，包括人类。有证据表明，AMP在多种生物环境中介导先天宿主防御。除了AMP通过膜破坏机制的杀微生物作用之外，研究表明某些哺乳动物AMP也具有受体介导的炎症相关活性，支持AMP是多功能宿主防御效应分子的假设。了解AMP在先天免疫应答中的作用将有助于更好地理解人类疾病的病理生理学，包括囊性纤维化、性传播和机会性感染、牙周炎、炎症性肠病等。会议将重点关注这个相对年轻，迅速扩大的多学科研究领域。该计划将分为9个会议的口头报告和两个海报会议。将敦促所有与会者以其中一种形式发言。口头报告将包括由教授迈克尔Zasloff和罗伯特E. W.汉考克，7个口头会议（20分钟讲座+ 10分钟讨论），和10个简短的谈话，从关键海报选择，注意包括初级和学生的参与者。新设立的职业成就奖获得者将作简短的口头介绍。口头会议的主题是：AMP多样性和系统发生学，AMP合成的调节，AMP作用机制，发病机制和微生物耐药机制，AMP模型系统和先天免疫，AMP作用的生化/生物物理参数，以及微生物对抗菌剂的反应。与会者有充分的时间进行有组织的讨论和非正式互动。此外，一个会议，“热点和最新消息”将专门讨论当前调查的前沿话题。组织理念是鼓励多样化的参与，并关注性别问题、青年科学家、少数民族和身体有缺陷的个人。

DESCRPTION (provided by applicant):The fifth semi-annual Gordon Research Conference on Antimicrobial Peptides (AMPs) will meet in Ventura, California in March 6-11, 2005. The emergence of antibiotic-resistant microorganisms underscores the need to study of endogenous substances. AMPs are endogenous, gene-encoded antibiotics found in every species investigated, including invertebrates, plants, vertebrates, and mammals, including humans. Evidence shows that AMPs mediate innate host defense in a variety of biological settings. In addition to AMP microbicidal action by membrane disruptive mechanisms, studies show that certain mammalian AMPs also have receptor-mediated inflammation-associated activities, supporting the hypothesis that AMPs are multifunctional host defense effector molecules. Knowledge of the roles of AMPs in innate immune responses will contribute to improved understanding of the pathophysiology of human diseases, including cystic fibrosis, sexually transmitted and opportunistic infections, periodontitis, inflammatory bowel disease, and others. The conference will focus on this relatively young, rapidly expanding multidisciplinary field of study. The program will be divided into 9 sessions of oral presentations and two poster sessions. All participants will be urged to present in one of these formats. The oral presentations will include keynote addresses by Professors Michael Zasloff and Robert E. W. Hancock, 7 oral sessions (20 min lecture + 10 min discussion), and 10 short talks selected from key posters, with attention to include junior and student participants. A short oral presentation will be presented by the recipient of a newly-established Career Achievement Award. The themes of the oral sessions are: AMP Diversity and Phylogenetics, Regulation of AMP Synthesis, Mechanisms of AMP Action, Pathogenesis and Microbial Resistance Mechanisms, AMP Model Systems and Innate Immunity, Biochemical/Biophysical Parameters of AMP Action, and Microbial Responses to Antimicrobials. Ample time for organized discussion and informal interactions between participants has been included. In addition, one session, "Hot Corner and Late Breaking News" will be devoted to discussing topics at the cutting edge of current investigation. The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with physical limitations.