CORE--AUDITORY PHYSIOLOGY

生理学核心将为各个项目的研究人员提供综合服务。核心人员将与各项目负责人协调动物生理试验。听觉脑干反应将是评估所有项目听觉灵敏度的主要方法。将测量耳蜗内电位，以确定幼龄和老龄小鼠的血管纹状态。生理学核心还将根据每个研究者的暴露需求协调动物的噪声暴露，这些暴露将产生临时（ITS）或永久（PTS）阈值偏移，以满足需求 的项目。生理学核心将提供完成生理测量所需的所有标准材料和服务。将与数据管理团队一起分析和协调从本核心中描述的程序中获得的结果的统计学显著性，他们将作为顾问讨论数据解释和与其他结果的相关性。该核心将分析和编制图表，供在科学论坛上介绍和在科学期刊上发表。为了进一步促进有效和成功的核心运作，将经常举行会议，讨论研究进展， 新兴技术和协助未来的方向。制定了服务时间安排和优先次序以及质量控制的程序。组织学核心和生理学核心将密切合作，以协调实验条件下动物的生理学和形态学表征。

The Physiology Core will provide integrated services to the researchers of the individual projects. The Core personnel will work to coordinate physiological testing of animals with each individual project directors. The auditory brainstem response will be the primary method to evaluate auditory sensitivity across all projects. The endocochlear potential will be measured to address the status of stria vascularis in young and old mice. The Physiology Core will also coordinate noise exposures of animals with respect to each investigator's needs for exposures that will produce either temporary (ITS) or permanent (PTS) threshold shifts to meet the needs of the projects. The Physiology Core will provide all of the standard materials and services to accomplish the physiological measurements. The results obtained from the procedures described in this core will be analyzed and coordinated for statistical significance with the Data Management team and they will serve as consultants to discuss interpretation of data and correlation with other results. The Core will analyze and prepare graphs for presentation at scientific forums and publication in scientific journals. To further promote efficient and successful Core operation, frequent meetings will be used to discuss progress in research, emerging techniques and assist in future directions. Procedures are in place for scheduling and prioritization of services and quality control. The Histology Core and Physiology Core will work closely together to coordinate physiological and morphological characterization of animals under experimental conditions.