CONTRIBUTIONS OF EPISODIC MEMORY TO HEALTHY AGING

情景记忆对健康老龄化的贡献

• 批准号: 7095954
• 负责人: KATIE E CHERRY
• 金额: $ 8.55万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7095954
• 关键词: age difference; aging; apolipoprotein E; clinical research; cognition; exercise; functional ability; gene expression; human population genetics; human population study; human subject; memory; metabolism; performance; quality of life; questionnaires

Episodic memory is defined as memory for personally experienced events bound in unique space/time contexts. Independent living and quality of life are related to the maintenance of episodic memory. Thus, episodic memory in late life is an important research focus. The first aim of this project is to examine age differences in objective measures of memory and provide new evidence on the pictorial superiority effect as an episodic memory phenomenon in the oldest-old. The second aim is to examine the contribution of individual ability differences to episodic memory performance. The proposed individual difference variables include: a) general intellectual abilities, b) demographic characteristics, c) cognitive and affective status, and d) knowledge of memory aging. The third aim is to examine subjective memory appraisal in adulthood using self-report measures of memory functioning in everyday life. The fourth aim is to provide new evidence on the psychometric properties of the practical memory concerns in adulthood survey and examine relationships among our assessments of self-reported memory ability and objective memory performance. The fifth aim is to implement a pilot intervention to test the hypothesis that memory for everyday activities in daily life can be improved by providing illustrative pictures of the to-be-performed tasks during acquisition. In addition, we will examine relationships among measures of cognitive function and the genetic, metabolic, and physical functional outcome measures included in this proposal. Specifically, we will explore hypothesized relationships between APOE *4 (Project 1), vascular status and physical function (Project 4), and cognitive function (this Project). We also anticipate that relationships may exist between resting metabolic rate and total daily energy expenditure (Project 3) and self-reported health, social activity/lifestyle characteristics, and affective status (this Project). The multidisciplinary approach in this proposal permits a unique opportunity for assessment across multiple domains of functioning, which is essential for evolving a more complete understanding of age-related changes in cognitive status and memory functioning in very old age. Given the increased prevalence of cardiovascular disease and other chronic health conditions that adversely affect cognitive functioning in very old age, we anticipate that the present research will lead to the development of multidimensional criteria to define "healthy aging" in late life.

情景记忆被定义为在独特的空间/时间背景下个人经历过的事件的记忆。独立生活和生活质量与情景记忆的维持有关。因此，晚年的情景记忆是一个重要的研究热点。该项目的首要目标是检查客观记忆测量中的年龄差异，并为最年长者的情景记忆现象——图片优势效应提供新的证据。第二个目的是检查个体能力差异对情景记忆表现的影响。提出的个体差异变量包括：a）一般智力，b）人口特征，c）认知和情感状态，以及d）记忆老化知识。第三个目的是使用日常生活中记忆功能的自我报告测量来检查成年期的主观记忆评估。第四个目标是为成年调查中实际记忆问题的心理测量特性提供新的证据，并检查我们对自我报告记忆能力和客观记忆表现的评估之间的关系。 第五个目标是实施试点干预，以检验这样的假设：通过提供习得期间要执行的任务的说明性图片，可以改善日常生活中日常活动的记忆。此外，我们将研究本提案中包含的认知功能测量与遗传、代谢和身体功能结果测量之间的关系。具体来说，我们将探讨 APOE *4（项目 1）、血管状态和身体功能（项目 4）以及认知功能（本项目）之间的假设关系。我们还预计静息代谢率和每日总能量消耗（项目 3）与自我报告的健康、社交活动/生活方式特征和情感状态（本项目）之间可能存在关系。该提案中的多学科方法允许 跨多个功能领域进行评估的独特机会，这对于更全面地了解高龄认知状态和记忆功能与年龄相关的变化至关重要。鉴于心血管疾病和其他慢性健康状况的患病率增加，对老年认知功能产生不利影响，我们预计目前的研究将导致制定多维标准来定义晚年的“健康老龄化”。