Panic Disorder, Parenting and Infant Neurobiology

描述(由申请人提供)：这项研究将在父母患有恐慌症(PD)的高危样本中测试特定育儿行为与严重的父母焦虑症状、环境风险和保护因素相结合的影响模型，以检查儿童在出生后头两年的恐惧唤醒。来自两个父母诊断组的四个月大的婴儿将被研究，以增加风险的可能性：80名患有帕金森病母亲的婴儿和80名母亲没有精神疾病的婴儿。将在4个月、14个月和24个月大时评估婴儿对新刺激和唤醒的神经生物学指标(基线和增强惊吓、唾液皮质醇和睡眠障碍)的恐惧行为，以及父母的焦虑症状、特定的父母行为、环境风险和保护因素。 在此期间，照顾者与婴儿之间的相互作用有望在增加婴儿对体质脆弱婴儿的恐惧唤醒方面发挥重要作用。这项研究将提供关于哪些特定因素可能导致儿童在生命的头两年内增加恐惧唤醒的信息。

DESCRIPTION (provided by applicant): This research will test models concerning the impact of specified parenting behaviors in combination with severe symptoms of parental anxiety, environmental risk and protective factors, in a high-risk sample of children of parents with panic disorder (PD), in order to examine child fear arousal across the first two years of life. Four-month infants from two parental diagnostic groups will be studied in order to increment the likelihood of risk: eighty infants with PD mothers and eighty infants of mothers without psychopathology. Infant fearful behaviors in response to novel stimuli and neurobiological indicators of arousal (baseline and potentiated startle, salivary cortisol and sleep disturbances), along with parental anxiety symptoms, specified parenting behaviors, and environmental risk and protective factors, will be assessed at four, fourteen and twenty-four months of age. Caregiver-infant interactions are expected to play an important role in contributing to increasing infant fear-arousal for constitutionally vulnerable infants during this period. This research will provide information concerning which particular factors might contribute to increasing child fear-arousal across the first 2 years of life.