Panic Disorder, Parenting and Infant Neurobiology

恐慌症、育儿和婴儿神经生物学

• 批准号: 6838261
• 负责人: SUSAN Lisa WARREN
• 金额: $ 38万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838261
• 关键词: avoidance behavior; behavioral /social science research tag; child rearing; clinical research; fear; human subject; infant human (0-1 year); interview; neurobiology; panic disorder; parent offspring interaction; parents; questionnaires

DESCRIPTION (provided by applicant): This research will test models concerning the impact of specified parenting behaviors in combination with severe symptoms of parental anxiety, environmental risk and protective factors, in a high-risk sample of children of parents with panic disorder (PD), in order to examine child fear arousal across the first two years of life. Four-month infants from two parental diagnostic groups will be studied in order to increment the likelihood of risk: eighty infants with PD mothers and eighty infants of mothers without psychopathology. Infant fearful behaviors in response to novel stimuli and neurobiological indicators of arousal (baseline and potentiated startle, salivary cortisol and sleep disturbances), along with parental anxiety symptoms, specified parenting behaviors, and environmental risk and protective factors, will be assessed at four, fourteen and twenty-four months of age. Caregiver-infant interactions are expected to play an important role in contributing to increasing infant fear-arousal for constitutionally vulnerable infants during this period. This research will provide information concerning which particular factors might contribute to increasing child fear-arousal across the first 2 years of life.

描述（由申请人提供）：本研究将在父母患有恐慌症（PD）的儿童的高风险样本中测试特定养育行为与父母焦虑的严重症状、环境风险和保护因素相结合的影响模型，以检查儿童在生命的头两年中的恐惧唤起情况。将对来自两个父母诊断组的四个月婴儿进行研究，以增加风险的可能性：80 名患有 PD 母亲的婴儿和 80 名母亲没有精神病理学的婴儿。婴儿对新刺激和唤醒的神经生物学指标（基线和强化惊吓、唾液皮质醇和睡眠障碍）的恐惧行为，以及父母的焦虑症状、特定的养育行为以及环境风险和保护因素，将在四个、十四和二十四个月龄时进行评估。 在此期间，照顾者与婴儿的互动预计将在增加婴儿恐惧唤起方面发挥重要作用。这项研究将提供有关哪些特定因素可能导致儿童在生命的头两年内恐惧唤起程度增加的信息。