Panic Disorder, Parenting and Infant Neurobiology

描述（由申请人提供）：本研究将在父母患有惊恐障碍（PD）的儿童的高风险样本中测试有关指定养育行为与父母焦虑，环境风险和保护因素的严重症状相结合的影响的模型，以检查儿童在生命的前两年的恐惧唤醒。将研究来自两个父母诊断组的四个月婴儿，以增加风险的可能性：80名母亲患有PD的婴儿和80名母亲没有精神病理学的婴儿。在4、14和24个月大时，将评估婴儿对新刺激和唤醒的神经生物学指标（基线和增强惊吓、唾液皮质醇和睡眠障碍）的恐惧行为，沿着父母焦虑症状、指定的养育行为、环境风险和保护因素。 在此期间，看护者与婴儿的互动预计将在增加婴儿对体质脆弱婴儿的恐惧唤醒方面发挥重要作用。这项研究将提供有关哪些特定因素可能有助于在生命的前2年增加儿童恐惧唤醒的信息。

DESCRIPTION (provided by applicant): This research will test models concerning the impact of specified parenting behaviors in combination with severe symptoms of parental anxiety, environmental risk and protective factors, in a high-risk sample of children of parents with panic disorder (PD), in order to examine child fear arousal across the first two years of life. Four-month infants from two parental diagnostic groups will be studied in order to increment the likelihood of risk: eighty infants with PD mothers and eighty infants of mothers without psychopathology. Infant fearful behaviors in response to novel stimuli and neurobiological indicators of arousal (baseline and potentiated startle, salivary cortisol and sleep disturbances), along with parental anxiety symptoms, specified parenting behaviors, and environmental risk and protective factors, will be assessed at four, fourteen and twenty-four months of age. Caregiver-infant interactions are expected to play an important role in contributing to increasing infant fear-arousal for constitutionally vulnerable infants during this period. This research will provide information concerning which particular factors might contribute to increasing child fear-arousal across the first 2 years of life.