Optical Coherence Microscopy for Endoscopic Diagnostics

用于内窥镜诊断的光学相干显微镜

• 批准号: 7062332
• 负责人: AARON D AGUIRRE
• 金额: $ 4.43万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-16 至 2009-01-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062332
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biopsy; cell morphology; clinical research; confocal scanning microscopy; endoscopy; gastrointestinal imaging /visualization; gastrointestinal neoplasms; human subject; laboratory rabbit; miniature biomedical equipment; molecular /cellular imaging; neoplasm /cancer diagnosis; optical tomography; predoctoral investigator; preneoplastic state; surgery material /equipment; technology /technique development

DESCRIPTION (provided by applicant): The hypothesis of this proposal is that optical coherence microscopy (OCM), a combination of OCT with confocal microscopy, can enable cellular resolution endoscopic imaging of tissue morphology, thereby dramatically advancing the capabilities of either technique for endoscopic detection of early stage neoplasms. An endoscopic "optical biopsy" technique that allows for real time, in vivo imaging of precancerous changes at the cellular level would allow image guidance of traditional excisional biopsy, potentially reducing sampling error and improving sensitivity. The specific aims are: 1) Develop optical coherence microscopy (OCM) technology for cellular imaging of unstained tissues. 2) Investigate OCM for detecting early neoplastic cellular alterations in human tissues through ex vivo clinical imaging studies. 3) Develop miniaturized flexible endoscopes for OCM imaging based on micro-electro-mechanical systems (MEMS) scanning technology. 4) Validate flexible OCM endoscopes through in vivo animal imaging experiments. These studies combined seek to demonstrate fundamental new advances for endoscopic detection of early stage neoplasms.

描述（由申请人提供）：该提案的假设是光学相干显微镜（OCM）是OCT与共聚焦显微镜的组合，可以使组织形态学的细胞分辨率内窥镜化成像，从而极大地提高了两种技术的能力，以实现早期阶段型肾上腺素的内窥镜检测能力。内窥镜“光学活检”技术，可以实时进行实时，在细胞水平上进行癌前变化的体内成像将允许对传统的移动活检的图像引导，从而降低采样误差并提高敏感性。具体目的是：1）开发用于未染色组织的细胞成像的光学相干显微镜（OCM）技术。 2）研究通过离体临床成像研究检测人体组织中早期肿瘤细胞改变的OCM。 3）开发基于微机械系统（MEMS）扫描技术的OCM成像的小型柔性内窥镜。 4）通过体内动物成像实验验证柔性OCM内窥镜。这些研究结合起来，试图证明内窥镜检测早期肿瘤的基本进展。