Chemosensory Processing in the Amygdala

杏仁核的化学感应处理

• 批准号: 7056955
• 负责人: CHAD L SAMUELSEN
• 金额: $ 3.18万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056955
• 关键词: amygdala; animal communication behavior; behavioral /social science research tag; chemoreceptors; estrus; ethology; gender difference; gene expression; genetically modified animals; hormone inhibitor; hormone receptor; immunocytochemistry; laboratory mouse; neural information processing; neurohormones; neuropsychology; neuroregulation; olfactions; oxytocin; predoctoral investigator; regulatory gene; social behavior; vomeronasal systems

Chemosensory signals activate brain regions along the vomeronasal and main olfactory pathways. In male hamsters, socially relevant chemosignals.from the same species of animal (conspecific) activate the anterior medal amygdala (MeA) and the posterior medial amygdala (MeP) and do not activate the GABATergic intercalated nucleus (ICN). Socially non-relevant chemosignals from other species activate MeA and ICN, but fail to activate MeP. Oxytocin knockout mice (OTKO) fail to recognize a conspecific that they have encountered previously. The cFos patterns in the medial amygdala suggest a heterospecific-like response to the stimulus animal. Therefore it is possible that oxytocin (OT) mediates the signal from the vomeronasal system in the medial amygdala allowing for "downstream" continuation of the signal. These and other data suggest that oxytocin (OT) may affect medial amygdala responses to socially-relevant and socially nonrelevant stimuli differently. This proposal will investigate OT effects in medial amygdala in response to conspecific and heterospecific chemosensory stimulation.

化学感觉信号激活沿犁鼻和主要嗅觉通路的大脑区域。在雄性仓鼠中，来自同一物种(同种)的社会相关化学信号激活杏仁前内侧核(MEA)和杏仁内侧后核(MEP)，而不激活GABA能夹层核(ICN)。来自其他物种的社会无关化学信号可激活MeA和ICN，但不能激活MEP。催产素基因敲除小鼠(OTKO)无法识别它们以前遇到的同种动物。杏仁内侧核的CFO模式表明，对刺激动物的反应是异种的。因此，催产素(OT)可能是从杏仁内侧的犁鼻系统传递的信号，从而允许信号的“下游”延续。这些和其他数据表明，催产素(OT)可能以不同的方式影响杏仁内侧核对社会相关刺激和社会无关刺激的反应。这项建议将研究同种和异种化学感觉刺激对杏仁内侧核的OT效应。