The molecular basis of reproductive isolation

描述（由申请人提供）：本研究旨在确定有助于模式植物小立碗藓及其野生亲缘植物梨形立碗藓之间生殖隔离的相互作用位点。经典遗传学和现代基因组学方法的组合将用于识别在杂交遗传背景中不能正确相互作用的基因。功能基因座之间的这种适应不良的相互作用可能导致人类各种复杂的疾病。P.patens模型提供了一个简单的遗传系统，其中多位点相互作用的分子遗传学可以容易地操纵和研究。识别复杂性状（如生殖隔离）背后的分子变异，为研究适应和物种形成的特定机制开辟了几条新途径。

DESCRIPTION (provided by applicant): This research is aimed at identifying interacting loci that contribute to reproductive isolation between the model plant Physcomitrella patens and its wild relative Physcomitrium pyriforme. A combination of classical genetic and modern genomic approaches will be used to identify genes that fail to interact properly in a hybrid genetic background. Such maladaptive interactions among functional loci may contribute to a wide variety of complex diseases in humans. The P. patens model provides a simple genetic system where the molecular genetics of multilocus interactions can be easily manipulated and studied. The identification of molecular variants underlying complex traits, like reproductive isolation, opens several new avenues of research into the specific mechanisms of adaptation and speciation.