For everything you have missed, you have gained something else: Impact of novel splicing events in human

对于您错过的一切，您已经获得了其他东西：新型剪接事件对人类的影响

• 批准号: 2578660
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2578660
• 关键词: everything; missed; gained; something; else

Nearly all the genes in human undergo alternative splicing, the process through which different transcripts are generated from a single gene. Despite the observation of the universality of alternative splicing in Eukaryotes, tissue and developmental stage specific regulation of splicing, and the importance of this mechanism in fundamental biological processes, much remains to be discovered regarding the function of alternatively spliced transcripts. The most recent studies point at a vast underestimation in transcript diversity. As a result, thousands of novel transcripts and exons in both human and mouse studies have already been identified.The main aim of the project is to investigate the evolution, function, and expressionacross development and cells of novel alternative splicing events in human and mouse. A specific focus on those with lineage (primates, rodents), or species (human, mouse)-specific evolution.

人类几乎所有的基因都经历了选择性剪接，这是一个从单个基因产生不同转录本的过程。尽管观察到选择性剪接在真核生物中的普遍性，剪接的组织和发育阶段特异性调节，以及这种机制在基本生物过程中的重要性，但关于选择性剪接转录本的功能仍有待发现。最新的研究指出，在转录多样性的巨大低估。因此，在人类和小鼠的研究中已经鉴定出了数千种新的转录本和外显子。该项目的主要目的是研究人类和小鼠中新的选择性剪接事件的进化、功能和跨发育和细胞的表达。特别关注那些具有谱系（灵长类动物，啮齿类动物）或物种（人类，小鼠）特定进化的人。