Biological computation for programmed applications of biomineralized photosynthetic engineered living material (BP-ELM)

生物矿化光合工程生命材料编程应用的生物计算（BP-ELM）

• 批准号: 2585623
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2585623
• 关键词: Biological; computation; programmed; applications; biomineralized

This project seeks to define parameters to scale up Engineered Living Materials for low-carbon construction. Using a novel process of photosynthetically mediated biomineralization, the proposed research seeks to produce bulk solid phase materials using cyanobacterial organisms. This presents a manufacturing opportunity to create light-powered, carbon negative living architecture, reducing the footprint of our built environment. The research will use biochemical engineering techniques to achieve a goal of programmable animate materials. Experimental characterisation of the biophysical (gas transfer, light wavelength) and biochemical parameters (nutrients) governing growth of the cyanobacterial species capable of biomineralisation will be conducted in order to determine the stimuli-response relationships. Dynamics will be analysed through machine learning to create a semantic data model and applied digitally to simulate the behaviour of the BP-ELM. A design-build-test cycle will be adopted to refine the model through fabrication of scale-up prototypes. This will establish which biological stimuli will become input parameters to define material properties and inform on-demand growth and regeneration.To deliver this project, the student will receive training in bioprocess scale up techniques and advanced robotic manufacturing. The proposal is aligned with the remit of Bio-ID, and has evolved out of the independent, original research of Mr.Tamuli.EPSRC remit:All projects must lie within EPSRC's remit. Please provide at least 1 and up to 3 of EPSRC's research areas that this project fits within. The list of research areas are available on EPSRC's website.

该项目寻求定义参数，以扩大用于低碳建筑的工程生物材料的规模。利用一种新的光合作用介导的生物矿化过程，这项拟议的研究试图利用蓝藻生物来生产块状固相材料。这提供了一个制造机会来创造光能、碳负向生活建筑，减少我们建筑环境的足迹。这项研究将利用生化工程技术来实现可编程动画材料的目标。将对能够生物矿化的蓝藻物种的生物物理(气体传输、光波长)和生化参数(营养)进行实验表征，以确定刺激-反应关系。将通过机器学习来分析动力学，以创建语义数据模型，并以数字方式应用于模拟BP-ELM的行为。将采用设计-建造-测试周期，通过制造放大原型来改进模型。这将确定哪些生物刺激将成为定义材料属性的输入参数，并通知按需生长和再生。为了交付此项目，学生将接受生物工艺放大技术和先进机器人制造方面的培训。该提案与Bio-ID的职权范围一致，并由Tamuli先生的独立原创研究演变而来。EPSRC的职权范围：所有项目必须在EPSRC的职权范围内。请提供至少1至最多3个EPSRC的研究领域，该项目适用于该领域。研究领域的清单可在EPSRC的网站上查阅。