Psychological distress in survivors of head/neck cancer

头颈癌幸存者的心理困扰

• 批准号: 6849615
• 负责人: HENRIETTA L LOGAN
• 金额: $ 18.77万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-26 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6849615
• 关键词: behavioral /social science research tag; cancer registry /resource; clinical research; data collection methodology /evaluation; functional ability; head /neck neoplasm; human population study; human subject; interview; long term survivor; longitudinal human study; medical outreach /case finding; neoplasm /cancer diagnosis; psychological adaptation; psychological aspect of cancer; psychological stressor; quality of life

DESCRIPTION (provided by applicant): The overall aim of this R21 application is to facilitate the study of head and neck cancer survivorship. This will be accomplished via two specific aims: 1. Identify the most appropriate and cost-effective control group for head and neck cancer survivors. 2. Gather pilot data on psychological distress for a future R01 application to study long-term survivors (5-years and more beyond diagnosis) of head and neck cancer. Part of the challenge of conducting long-term cancer survivorship research is to identify an appropriate control group. This is especially true in head and neck cancer because the disease disproportionately affects older, ethnoracially diverse men who may be from a lower socioeconomic stratum. To achieve our aim we will recruit 100 long-term survivors from the tumor registry to participate in a telephone interview regarding psychological distress, quality of life, and physical function. Two control groups will be utilized. First, as part of the interview, survivors will be asked to identify 2-3 friends of the same sex, age, race, and work status, with no history of cancer, and who would be willing to take part in a similar 30-minute telephone interview. This is the most likely method to yield a control group that is demographically similar to the survivor group. The disadvantage of this approach is that some survivors may be unwilling or unable to identify friends who would participate and some survivors may nominate several friends, potentially biasing the control group. Using random digit dial (RDD) methodology, a second control group (n=100) will be drawn from the survivors' census tracts and frequency matched on sex, age, and race of the cancer survivor group. In the current atmosphere, the yield rate from RDD calls is low. Additionally, older individuals may be suspicious of telephone interviewers, thus it is unclear whether this is the most cost-effective methodology for recruiting an appropriate control group. Between-group comparisons will be conducted to determine which control group yields the best match with the survivor group on sex, age, occupation, socioeconomic status, and race. A final goal of this project will be to collect pilot data for an R01 application. Data will be compared to population-based norms for older men on standardized indices, as well as on illness-specific indices appropriate for this population. Normative data, effect sizes for determination of future sample size requirements, and cost-effectiveness of control group selection methodologies will be established for survivorship research in this understudied population.

描述（由申请人提供）：本R21申请的总体目标是促进头颈癌生存率的研究。 这将通过两个具体目标来实现：1。为头颈癌幸存者确定最合适和最具成本效益的对照组。 2.收集有关心理困扰的试点数据，用于未来的R 01应用程序，以研究头颈癌的长期幸存者（诊断后5年及以上）。 进行长期癌症生存率研究的部分挑战是确定一个适当的对照组。 头颈部癌症尤其如此，因为这种疾病不成比例地影响年龄较大，种族多样的男性，他们可能来自较低的社会经济阶层。 为了实现我们的目标，我们将从肿瘤登记处招募100名长期幸存者，参加关于心理困扰，生活质量和身体功能的电话访谈。 将使用两个对照组。 首先，作为访谈的一部分，幸存者将被要求确定2-3个相同性别，年龄，种族和工作状态的朋友，没有癌症病史，并且愿意参加类似的30分钟电话访谈。 这是最有可能产生与幸存者组在人口统计学上相似的对照组的方法。 这种方法的缺点是，一些幸存者可能不愿意或无法确定谁会参加，一些幸存者可能会提名几个朋友，可能会偏向控制组的朋友。 使用随机数字拨号（RDD）方法，从幸存者的人口普查区域中抽取第二个对照组（n=100），并在癌症幸存者组的性别、年龄和种族上进行频率匹配。 在目前的氛围下，RDD呼叫的收益率很低。 此外，老年人可能会怀疑电话面试，因此目前还不清楚这是否是最具成本效益的方法，招募一个适当的控制组。 将进行组间比较，以确定哪个对照组在性别、年龄、职业、社会经济地位和种族方面与幸存者组最匹配。 本项目的最终目标是为R 01应用收集试验数据。 将根据标准化指数以及适合于这一人群的疾病特异性指数，将数据与基于人口的老年男性规范进行比较。 将建立规范数据、用于确定未来样本量要求的效应量和对照组选择方法的成本效益，以用于该研究不足人群的生存率研究。